Solution Manual for Molecular Cell Biology, 8th Edition, Harvey Lodish; Arnold Berk; Chris A. Kaiser; Monty Krieger; Anthony Bretscher; Hidde Ploegh; Angelika Amon; Kelsey C. Martin

Product details:

• ISBN-10 ‏ : ‎ 1464183392
• ISBN-13 ‏ : ‎ 978-1464183393
• Author: Harvey Lodish; Arnold Berk; Chris A. Kaiser; Monty Krieger; Anthony Bretscher; Hidde Ploegh; Angelika Amon; Kelsey C. Martin

Grounding its coverage in experiments, Molecular Cell Biology emphasizes medical relevance while fousing on the information which defines our understanding of cell biology.

Table contents:

Part I. Chemical and Molecular Foundations

1. Molecules, Cells, and Model Organisms

Model organisms Chlamydomonas reinhardtii (for study of flagella, chloroplast formation, photosynthesis, and phototaxis) and Plasmodium falciparum (novel organelles and a complex life cycle)

2. Chemical Foundations

3. Protein Structure and Function

Intrinsically disordered proteins

Chaperone-guided folding and updated chaperone structures

Unfolded proteins and the amyloid state and disease

Hydrogen/deuterium exchange mass spectrometry (HXMS)

Phosphoproteomics

4. Culturing and Visualizing Cells

Two-photon excitation microscopy

Light sheet microscopy

Super resolution microscopy

3D culture matricies and 3D printing

Part II. Biomembranes, Genes, and Gene Regulation

5. Fundamental Molecular Genetic Mechanisms

Ribosome structural comparison across domains shows conserved core

6. Molecular Genetic Techniques

CRISPR/Cas9 system in bacteria and its application in genomic editing

7. Biomembrane Structure

8. Genes, Genomics, and Chromosomes

Chromosome conformation capture techniques reveal topological domains in chromosome territories within the nucleus

9. Transcriptional Control of Gene Expression

DNase I hypersensitivity mapping reveals cell developmental history

Long non-coding RNAs involved in X-inactivation in mammals

ENCODE databases

10. Post-transcriptional Gene Control

Improved discussion of mRNA degradation pathways and RNA surveillance in the cytoplasm

Nuclear bodies: P bodies, Cajal bodies, histone locus bodies, speckles, paraspeckles, and PML-nuclear bodies

Part III. Cellular Organization and Function

11. Transmembrane Transport of Ions and Small Molecules

GLUT1 molecular model and transport cycle

12. Cellular Energetics

13. Moving Proteins into Membranes and Organelles

Expanded discussion of the pathway for import of PTS1-bearing proteins into the peroxisomal matrix

14. Vesicular Traffic, Secretion, and Endocytosis

Expanded discussion of Rab proteins and their role in vesicle fusion with target membranes

15. Signal Transduction and G Protein–Coupled Receptors

Human G protein-coupled receptors of pharmaceutical importance

16. Signaling Pathways That Control Gene Expression

Wnt concentration gradients in planaria development and regeneration

Inflammatory hormones in adipose cell function and obesity

Regulation of insulin and glucagon function in control of blood glucose

17. Cell Organization and Movement I: Microfilaments

Use of troponins as an indicator of the severity of a heart attack

18. Cell Organization and Movement II: Microtubules and Intermediate Filaments

Neurofilaments and keratins involved in skin integrity, epidermolysus bullosa simplex

New structures and understanding of function of dynein and dynactin

19. The Eukaryotic Cell Cycle

The Hippo pathway

Spindle checkpoint assembly and nondisjunction and aneuploidy in mice, and nondisjunction increases with maternal age

Part IV. Cell Growth and Differentiation

20. Integrating Cells Into Tissues

Expanded discussion of the functions of the extracellular matrix and the role of cells in assembling it

Mechanotransduction

Structure of cadherins and their cis and trans interactions

Cadherins as receptors for Class C rhinoviruses and asthma

Improved discussion of microfibrils in elastic tissue and in LTBP-mediated TGF-B signaling

Tunneling nanotubes

Functions of WAKs in plants as pectin receptors

21. Stem Cells, Cell Asymmetry, and Cell Death

Pluripotency of mouse ES cells and the potential of differentiated cells derived from iPS and ES cells in treating various diseases

Pluripotent ES cells in planaria

Cells in intestinal crypts can dedifferentiate to replenish intestinal stem cells

Cdc42 and feedback loops that control cell polarity

22. Cells of the Nervous System

Prokaryotic voltage-gated Na+ channel structure, allowing comparison with voltage-gated K+ channels

Optogenetics techniques for linking neural circuits with behavior

Mechanisms of synaptic plasticity that govern learning and memory

23. Immunology

Inflammasomes and non-TLR nucleic sensors

Expanded discussion of somatic hypermutation

Improved discussion of the MHC molecule classes, MHC-peptide complexes and their interactions with T-cells

Lineage commitment of T cells

Tumor immunology

24. Cancer

The characteristics of cancer cells and how they differ from normal cells

How carcinogens lead to mutations and how mutations accumulate to cancer

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