Instant download Solutions Manual to accompany Molecular Biology of the Gene 6th edition 9780805395921 pdf docx epub after payment.
Product details:
- ISBN-10 : 080539592X
- ISBN-13 : 978-0805395921
- Author: James D. Watson;
This sixth edition of James D. Watson’s classic textbook Molecular Biology of the Gene has been thoroughly revised and updated. Accessible to anyone interested in molecular biology and genetics, the book provides a historical basis for the field, concise descriptions of fundamental chemical
concepts, a comprehensive survey of genome maintenance and expression, and a discussion of standard techniques and model organisms commonly used in molecular biology studies. It includes all new chapters on the regulatory RNAs and genomics and systems biology. The book has an accompanying Web site
(www.aw-bc.com/watson/), which contains interactive tutorials, animations, and criticalDSthinking exercises designed to help students explore and visualize complex concepts.
Table of contents:
- Acknowledgments
- Preface
- A Note to the Reader
- Part I. Introduction to the Cell
- Chapter 1. Cells and Genomes
- The Universal Features of Cells on Earth
- All Cells Store Their Hereditary Information in the Same Linear Chemical Code (DNA)
- All Cells Replicate Their Hereditary Information by Templated Polymerization
- All Cells Transcribe Portions of Their Hereditary Information into the Same Intermediary Form (RNA)
- All Cells Use Proteins as Catalysts
- All Cells Translate RNA into Protein in the Same Way
- The Fragment of Genetic Information Corresponding to One Protein Is One Gene
- Life Requires Free Energy
- All Cells Function as Biochemical Factories Dealing with the Same Basic Molecular Building Blocks
- All Cells Are Enclosed in a Plasma Membrane Across Which Nutrients and Waste Materials Must Pass
- A Living Cell Can Exist with Fewer Than 500 Genes
- Summary
- The Diversity of Genomes and the Tree of Life
- Cells Can Be Powered by a Variety of Free Energy Sources
- Some Cells Fix Nitrogen and Carbon Dioxide for Others
- The Greatest Biochemical Diversity Is Seen Among Procaryotic Cells
- The Tree of Life Has Three Primary Branches: Bacteria, Archaea, and Eucaryotes
- Some Genes Evolve Rapidly; Others Are Highly Conserved
- Most Bacteria and Archaea Have 1000–4000 Genes
- New Genes Are Generated from Preexisting Genes
- Gene Duplications Give Rise to Families of Related Genes Within a Single Cell
- Genes Can Be Transferred Between Organisms, Both in the Laboratory and in Nature
- Horizontal Exchanges of Genetic Information Within a Species Are Brought About by Sex
- The Function of a Gene Can Often Be Deduced from Its Sequence
- More Than 200 Gene Families Are Common to All Three Primary Branches of the Tree of Life
- Mutations Reveal the Functions of Genes
- Molecular Biologists Have Focused a Spotlight on E. coli
- Summary
- Genetic Information in Eucaryotes
- Eucaryotic Cells May Have Originated as Predators
- Eucaryotic Cells Evolved from a Symbiosis
- Eucaryotes Have Hybrid Genomes
- Eucaryotic Genomes Are Big
- Eucaryotic Genomes Are Rich in Regulatory DNA
- The Genome Defines the Program of Multicellular Development
- Many Eucaryotes Live as Solitary Cells: the Protists
- A Yeast Serves as a Minimal Model Eucaryote
- The Expression Levels of All The Genes of An Organism Can Be Monitored Simultaneously
- Arabidopsis Has Been Chosen Out of 300,000 Species As a Model Plant
- The World of Animal Cells Is Represented By a Worm, a Fly, a Mouse, and a Human
- Studies in Drosophila Provide a Key to Vertebrate Development
- The Vertebrate Genome Is a Product of Repeated Duplication
- Genetic Redundancy Is a Problem for Geneticists, But It Creates Opportunities for Evolving Organisms
- The Mouse Serves as a Model for Mammals
- Humans Report on Their Own Peculiarities
- We Are All Different in Detail
- Summary
- References
- General
- The Universal Features of Cells on Earth
- The Diversity of Genomes and the Tree of Life
- Genetic Information in Eucaryotes
- The Universal Features of Cells on Earth
- Chapter 2. Cell Chemistry and Biosynthesis
- The Chemical Components of a Cell
- Cells Are Made From a Few Types of Atoms
- The Outermost Electrons Determine How Atoms Interact
- Ionic Bonds Form by the Gain and Loss of Electrons
- Covalent Bonds Form by the Sharing of Electrons
- There Are Different Types of Covalent Bonds
- An Atom Often Behaves as if It Has a Fixed Radius
- Water Is the Most Abundant Substance in Cells
- Some Polar Molecules Form Acids and Bases in Water
- Four Types of Noncovalent Interactions Help Bring Molecules Together in Cells
- A Cell Is Formed from Carbon Compounds
- Cells Contain Four Major Families of Small Organic Molecules
- Sugars Provide an Energy Source for Cells and Are the Subunits of Polysaccharides
- Fatty Acids Are Components of Cell Membranes
- Amino Acids Are the Subunits of Proteins
- Nucleotides Are the Subunits of DNA and RNA
- The Chemistry of Cells is Dominated by Macromolecules with Remarkable Properties
- Noncovalent Bonds Specify Both the Precise Shape of a Macromolecule and its Binding to Other Molecules
- Summary
- Catalysis and the Use of Energy by Cells
- Cell Metabolism Is Organized by Enzymes
- Biological Order Is Made Possible by the Release of Heat Energy from Cells
- Photosynthetic Organisms Use Sunlight to Synthesize Organic Molecules
- Cells Obtain Energy by the Oxidation of Organic Molecules
- Oxidation and Reduction Involve Electron Transfers
- Enzymes Lower the Barriers That Block Chemical Reactions
- How Enzymes Find Their Substrates: The Importance of Rapid Diffusion
- The Free-Energy Change for a Reaction Determines Whether It Can Occur
- The Concentration of Reactants Influences ΔG
- For Sequential Reactions, ΔG° Values Are Additive
- Activated Carrier Molecules are Essential for Biosynthesis
- The Formation of an Activated Carrier Is Coupled to an Energetically Favorable Reaction
- ATP Is the Most Widely Used Activated Carrier Molecule
- Energy Stored in ATP Is Often Harnessed to Join Two Molecules Together
- NADH and NADPH Are Important Electron Carriers
- There Are Many Other Activated Carrier Molecules in Cells
- The Synthesis of Biological Polymers Requires an Energy Input
- Summary
- How Cells Obtain Energy from Food
- Food Molecules Are Broken Down in Three Stages to Produce ATP
- Glycolysis Is a Central ATP-producing Pathway
- Fermentations Allow ATP to Be Produced in the Absence of Oxygen
- Glycolysis Illustrates How Enzymes Couple Oxidation to Energy Storage
- Sugars and Fats Are Both Degraded to Acetyl CoA in Mitochondria
- The Citric Acid Cycle Generates NADH by Oxidizing Acetyl Groups to CO2
- Electron Transport Drives the Synthesis of the Majority of the ATP in Most Cells
- Organisms Store Food Molecules in Special Reservoirs
- Amino Acids and Nucleotides Are Part of the Nitrogen Cycle
- Many Biosynthetic Pathways Begin with Glycolysis or the Citric Acid Cycle
- Metabolism Is Organized and Regulated
- Summary
- References
- General
- The Chemical Components of a Cell
- Catalysis and the Use of Energy by Cells
- How Cells Obtain Energy from Food
- The Chemical Components of a Cell
- Chapter 1. Cells and Genomes
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