Test Bank for Clinical Immunology and Serology A Laboratory Perspective, 3rd Edition: Stevens

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Product details:

• ISBN-10 ‏ : ‎ 080361814X
• ISBN-13 ‏ : ‎ 978-0803618145
• Author:  F.A. Davis Company

This title is completely updated to include new information about the immune system and new treatments for immunological diseases! This practical introduction to clinical immunology covers all of the essential theoretical principles and the serology techniques most commonly used in the laboratory. Structured into easy-to-read, student-friendly sections, the 3rd edition focuses on the direct application of theory to clinical laboratory practice. The pedagogical structure for each chapter includes: chapter outlines; key terms; objectives; multiple-choice review questions with answer keys case studies; and, chapter summaries. Case studies make topics more relevant and help to explain the ‘big picture’. Each chapter is a complete learning module that contains theoretic principles, illustrations, definitions of relevant terminology, procedures for simulated clinical testing, and questions and case studies that help to evaluate learning. There is an insert that features full-color slides that visually demonstrate what to expect in the lab and show the relationship between immunology and hematology. Updated references and additional lab exercises reflect changes in immunology and serology. Lab exercises are designed to illustrate and reinforce principles discussed in the chapters. 

Table of contents:

1. Section 1. Nature of the Immune System
2. Chapter 1. Introduction and Natural Immunity
3. And Immunization
4. Versus Humoral Immunity
5. External Defense System
6. Internal Defense System
7. Acute-Phase Reactants
8. Cellular Defense Mechanisms
9. Phagocytosis
10. Inflammation
11. Summary
12. Chapter 2. The Lymphoid System
13. Primary Lymphoid Organs
14. Bone Marrow
15. Thymus
16. Secondary Lymphoid Organs
17. Spleen
18. Lymph Nodes
19. Other Secondary Organs
20. Surface Markers On Lymphocytes
21. Stages In B-Cell Differentiation
22. Pro-B Cells
23. Pre-B Cells
24. Immature B Cells
25. Mature B Cells
26. Activated B Cells
27. Plasma Cells
28. T-Cell Differentiation
29. Double-Negative Stage
30. Double-Positive Stage
31. Mature T Cells
32. Antigen Activation
33. Third Population Or Natural Killer Cells
34. Mechanism of Cytotoxicity
35. Antibody-Dependent Cell Cytotoxicity
36. Laboratory Identification Of Lymphocytes
37. Manual Method
38. Summary
39. Chapter 3. Nature of Antigens and the Major Histocompatibility Complex
40. Factors Influencing The Immune Response
41. Traits Of Immunogens
42. Nature Of Epitopes
43. Haptens
44. Relationship Of Antigens To The Host
45. Adjuvants
46. Major Histocompatibility Complex
47. Genes Coding for MHC Molecules (HLA Antigens)
48. Structure of Class I Molecules
49. Structure of Class Ii Molecules
50. Role of Class I Molecules
51. Role of Class Ii Molecules
52. Clinical Significance of Mh
53. Summary
54. Chapter 4. Antibody Structure and Function
55. Tetrapeptide Structure Of Immunoglobulins
56. Cleavage with Papain
57. Pepsin Digestion
58. The Nature Of Light Chains
59. Heavy Chain Sequencing
60. Hinge Region
61. Three-Dimensional Structure Of Antibodies
62. IgG
63. IgM
64. IgA
65. IgD
66. IgE
67. Antibody Diversity
68. Ehrlich’s Side-Chain Theory
69. Clonal Selection
70. Genes Coding For Immunoglobulins
71. Rearrangement of Heavy Chain Genes
72. Light Chain Rearrangement
73. Monoclonal Antibody
74. Hybridoma Production
75. Selection of Specific Antibody-Producing Clones
76. Clinical Applications
77. Summary
78. Chapter 5. Cytokines
79. Introduction To Cytokines
80. Cytokines In The Innate Immune Response
81. Interleukin-1 (Il-1)
82. Tumor Necrosis Factor-
83. Il-6
84. Chemokines
85. Tgf-ß
86. Ifn-a and Ifn-ß
87. Cytokines In The Adaptive Immune Response
88. Th1 Cytokines
89. Th2 Cytokines
90. Cytokines Associated with T Regulatory Cells
91. Erythropoietin And Colony Stimulating Factors
92. Cytokines And Anticytokine Therapies
93. Clinical Assays For Cytokines
94. Summary
95. Chapter 6. Complement System
96. The Classical Pathway
97. Recognition Unit
98. Activation Unit
99. The Membrane Attack Complex
100. The Alternative Pathway
101. The Lectin Pathway
102. System Controls
103. Regulation of the Classical and Lectin Pathways
104. Regulation of the Alternative Pathway
105. Regulation of Terminal Components
106. Complement Receptors And Their Biological Roles
107. Biological Manifestations Of Complement Activation
108. Complement And Disease States
109. Complement Deficiencies
110. Major Pathway Components
111. Regulatory Factor Components
112. Laboratory Detection Of Complement Abnormalities
113. Immunologic Assays of Individual Components
114. Assays for the Classical Pathway
115. Alternative Pathway Assays
116. Interpretation of Laboratory Findings
117. Complement Fixation Testing
118. Summary
119. Section 2. Basic Immunological Procedures
120. Chapter 7. Safety and Specimen Preparation
121. Biological Hazards
122. Handwashing
123. Personal Protective Equipment
124. Procedure Precautions
125. Biological Waste Disposal
126. Transporting Patient Specimens
127. Sharps Hazards
128. Government Regulations
129. Occupational Exposure to Bloodborne Pathogens
130. Chemical Hazards
131. General Precautions
132. Material Safety Data Sheets
133. Chemical Hygiene Plan
134. Chemical Waste Disposal
135. Radioactive Hazards
136. General Precautions
137. Radioactive Waste Disposal
138. Serological Testing
139. Specimen Preparation and Processing
140. Simple Dilutions
141. Compound Dilutions
142. Summary
143. Chapter 8. Precipitation Reactions
144. Antigen–Antibody Binding
145. Affinity
146. Avidity
147. Law of Mass Action
148. Precipitation Curve
149. Zone of Equivalence
150. Prozone and Postzone
151. Measurement Of Precipitation By Light Scattering
152. Turbidimetry
153. Nephelometry
154. Passive Immunodiffusion Techniques
155. Radial Immunodiffusion
156. Ouchterlony Double Diffusion
157. Electrophoretic Techniques
158. Rocket Immunoelectrophoresis
159. Immunoelectrophoresis
160. Immunofixation Electophoresis
161. Sources of Error in Electrophoresis
162. Comparison Of Precipitation Techniques
163. Summary
164. Chapter 9. Agglutination
165. Steps In Agglutination
166. Sensitization
167. Lattice Formation
168. Enhancement of Lattice Formation
169. Types Of Agglutination Reactions
170. Direct Agglutination
171. Passive Agglutination
172. Reverse Passive Agglutination
173. Agglutination Inhibition
174. Coagglutination
175. Antiglobulin-Mediated Agglutination
176. Direct Antiglobulin Test
177. Indirect Antiglobulin Test
178. Instrumentation
179. Quality Control And Quality Assurance
180. Summary
181. Chapter 10. Labeled Immunoassays
182. Characteristics Of Labeled Assays
183. Competitive versus Noncompetitive Assays
184. Antibodies
185. Standards or Calibrators
186. Separation Methods
187. Detection of the Label
188. Quality Control
189. Radioimmunoassay
190. Competitive Binding Assays
191. Advantages and Disadvantages of Radioimmunoassay
192. Enzyme Immunoassay
193. Heterogeneous Enzyme Immunoassay
194. Rapid Immunoassays
195. Homogeneous Enzyme Immunoassay
196. Advantages and Disadvantages of Enzyme Immunoassay
197. Fluorescent Immunoassay
198. Direct Immunofluoescent Assays
199. Indirect Immunofluoescent Assays
200. Other Fluorescent Immunoassays
201. Advantages and Disadvantages of Fluorescent Immunoassay
202. Chemiluminescent Immunoassays
203. Principle of Chemiluminescence
204. Advantages and Disadvantages of Chemiluminescent Assays
205. Summary
206. Chapter 11. Molecular Diagnostic Techniques
207. Characteristics Of Nucleic Acids
208. Composition of DNA and RNA
209. Replication of DNA
210. Types of RNA
211. Hybridization Techniques
212. Solid Support Hybridization
213. Solution Hybridization
214. In Situ Hybridization
215. DNA Chip Technology
216. Drawbacks of Hybridization Techniques
217. DNA Sequencing
218. Target Amplification
219. Polymerase Chain Reaction
220. Transcription-Based Amplification
221. Strand Displacement Amplification (SDA)
222. Probe Amplification
223. Signal Amplification
224. Drawbacks Of Amplification Systems
225. Future Of Molecular Diagnostic Techniques
226. Summary
227. Chapter 12. Flow Cytometry and Laboratory Automation
228. Cell Flow Cytometry
229. Principle
230. Instrumentation
231. Data Acquisition and Analysis
232. Sample Preparation
233. Clinical Applications
234. Immunoassay Automation
235. Validation
236. Summary
237. Section 3. Immune Disorders
238. Chapter 13. Hypersensitivity
239. Type I Hypersensitivity
240. Triggering of Type I Reactions by IgE
241. Role of Mast Cells and Basophils
242. Mediators Released from Granules
243. Clinical Manifestations of Immediate Hypersensitivity
244. Treatment of Immediate Hypersensitivity
245. Testing for Immediate Hypersensitivity
246. Type II Hypersensitivity
247. Transfusion Reactions
248. Hemolytic Disease of the Newborn
249. Autoimmune Hemolytic Anemia
250. Type II Reactions Involving Tissue Antigens
251. Testing for Type Ii Hypersensitivity
252. Type III Hypersensitivity
253. Arthus Reaction
254. Serum Sickness
255. Autoimmune Diseases
256. Testing for Type Iii Hypersensitivity
257. Type IV Hypersensitivity
258. Contact Dermatitis
259. Hypersensitivity Pneumonitis
260. Tuberculin-Type Hypersensitivity
261. Testing for Delayed Hypersensitivity
262. Summary
263. Chapter 14. Autoimmunity
264. Systemic Lupus Erythematosus
265. Clinical Signs
266. Immunologic Findings
267. Laboratory Diagnosis of Systemic Lupus Erythematosus
268. Rheumatoid Arthritis
269. Clinical Signs
270. Immunologic Findings
271. Laboratory Diagnosis of Rheumatoid Arthritis
272. Treatment
273. Autoimmune Thyroid Diseases
274. Genetic Predisposition
275. Clinical Signs and Immunologic Findings for Hashimoto’s Thyroiditis
276. Clinical Signs and Immunologic Findings for Graves’ Disease
277. Laboratory Testing for Autoimmune Thyroid Diseases
278. Treatment for Autoimmune Thyroid Diseases
279. Type I Diabetes Mellitus
280. Immunopathology
281. Laboratory Testing
282. Treatment
283. Other Diseases
284. Multiple Sclerosis
285. Myasthenia Gravis
286. Goodpasture’s Syndrome
287. Summary
288. Chapter 15. Immunoproliferative Diseases
289. Concepts Of Malignant Transformation
290. Lymphomas
291. Hodgkin’s Lymphoma
292. Non-Hodgkin’s Lymphoma
293. Lymphoblastic Leukemias
294. Acute Lymphoblastic Leukemia
295. Chronic Lymphoid Leukemia/Lymphoma
296. Hairy Cell Leukemia
297. Plasma Cell Dyscrasias
298. Multiple Myeloma
299. Waldenström’s Macroglobulinemia
300. Role Of The Laboratory In Evaluating Immunoproliferative Diseases
301. Immunophenotyping by Flow Cytometry
302. Evaluation of Immunoglobulins
303. Serum Protein Electrophoresis
304. Immunofixation Electophoresis
305. Evaluation of Genetic and Chromosomal Abnormalities
306. Summary
307. Chapter 16. Immunodeficiency Diseases
308. Immunodeficiency Diseases
309. General Observations

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