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Test Bank for Hematology in Practice 3rd by Ciesla
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Test Bank for Hematology in Practice 3rd by Ciesla
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Product Details:
- ISBN-10 : 0803668244
- ISBN-13 : 978-0803668249
- Author:
I highly recommend this book.“… straight forward and I would recommend this book to anyone looking for a solid understanding of the most important concepts behind the tests performed in a modern hematology laboratory. Some textbooks today make it difficult for hematology students and lab professionals alike to figure out what it is that they “really need to know” to be effective and competent in the lab. Hematology in Practice addresses exactly this problem. In addition, this book will give a student an understanding that is more than good enough to pass general and categorical licensing exams.”—Michael B., Amazon Reviewer
Basic principles of hematology made memorable. Build a solid understanding of hematology in the context of practical laboratory practice and principles. Visual language, innovative case studies, role-playing troubleshooting cases, and laboratory protocols bring laboratory practice to life.
Superbly organized, this reader-friendly text breaks a complex subject into easy-to-follow, manageable sections. Begin with the basic principles of hematology; discover red and white blood cell disorders; journey through hemostasis and disorders of coagulation; and then explore the procedures needed in the laboratory.
Table of Content:
- Part I: Basic Hematology Principles
- Chapter 1: Introduction to Hematology and Basic Laboratory Practice
- Introduction to Hematology
- The Microscope
- Significant Parts of the Microscope
- Care of the Microscope
- Corrective Actions in Light Microscopy
- Innovations in Microscopy
- Standard Precautions
- Personal Protective Equipment
- Safety Practices Other Than Personal Protective Equipment
- Chemical and Environmental Hazards
- Basic Concepts of Quality Assurance Plans in the Hematology Laboratory
- Quality Control Monitoring in the Hematology Laboratory
- Reference Intervals
- Delta Checks
- Reflex Testing
- Critical Values
- Preanalytic Variables
- Postanalytic Variables
- Chapter 2: From Hematopoiesis to the Complete Blood Count
- Hematopoiesis: The Origin of Cell Development
- The Spleen as an Indicator Organ of Hematopoietic Health
- Functions of the Spleen
- Potential Risks of Splenectomy
- Bone Marrow and Myeloid:Erythroid Ratio
- Alterations in Myeloid:Erythroid Ratio
- Role of Stem Cells and Cytokines
- Erythropoietin
- Bone Marrow Analysis
- Bone Marrow Procedure
- Bone Marrow Report
- Complete Blood Count
- Morphologic Classification of Anemias
- Calculating Red Blood Cell Indices and Their Role in Indicating Sample Integrity
- Value of Red Blood Cell Distribution Width
- Critical Values
- Clinical Approach to Anemias
- Chapter 3: Red Blood Cell Production, Function, and Relevant Red Blood Cell Morphology
- Basic Red Blood Cell Production
- Red Blood Cell Maturation
- Features of Red Blood Cell Development
- Red Blood Cell Membrane Development and Function
- Composition of Lipids in the Interior and Exterior Layers
- Composition of Proteins in the Lipid Bilayers: Integral Proteins
- Cytoskeleton: Peripheral Proteins
- Red Blood Cell Metabolism
- Abnormal Red Blood Cell Morphology
- Variations in Red Blood Cell Size
- Variations in Red Blood Cell Color
- Variations in Red Blood Cell Shape
- Red Blood Cell Inclusions
- Value of the Reticulocyte Count
- Chapter 4: Hemoglobin Function and Principles of Hemolysis
- Hemoglobin Structure and Synthesis
- Genetics and Chain Formation of Hemoglobin
- Hemoglobin Function
- Oxygen Dissociation Curve
- Abnormal Hemoglobins
- Hemolysis
- Types and Physiology of Hemolysis
- Laboratory Evidence of Hemolysis
- Classifications Relevant to the Hemolytic Anemias
- Part II: Red Blood Cell Disorders
- Chapter 5: The Microcytic Anemias
- Introduction
- Iron Intake and Iron Absorption
- Iron Storage and Recycled Iron
- Iron Deficiency Anemia
- Pathophysiology and Symptoms
- Tests Used to Help Diagnose Iron Deficiency
- Treatment for Iron Deficiency
- Anemia of Chronic Disease and Inflammation: Pathophysiology, Diagnosis, and Treatment
- Sideroblastic Anemias
- Hereditary Hemochromatosis (Congenital Iron Overload)
- Thalassemia Syndromes
- Pathophysiology of Thalassemias
- Alpha Thalassemia
- Beta Thalassemia Major: Cooley’s Anemia, Mediterranean Anemia
- Thalassemia Intermedia and Beta Thalassemia Trait
- Chapter 6: The Macrocytic Anemias
- Macrocytic Anemias and the Megaloblastic Process
- Red Blood Cell Precursors in Megaloblastic Anemia
- Ineffective Erythropoiesis in Megaloblastic Anemia
- Pernicious Anemia as a Subset of Megaloblastic Anemias
- Vitamin B12 and Folic Acid: Nutritional Requirements and Metabolism
- Vitamin B12 and Folic Acid Deficiency
- Vitamin B12 Transport Into the Bone Marrow
- Clinical Features of Patients With Megaloblastic Anemia
- Hematologic Features of Megaloblastic Anemias
- Laboratory Diagnosis of Megaloblastic Anemias
- Serum Vitamin B12 Levels and Folic Acid Levels
- Serum Methylmalonic Acid and Homocysteine
- Intrinsic Factor and Parietal Cell Antibodies
- Treatment and Response of Patients With Megaloblastic Anemia
- Macrocytic Anemias That Are Not Megaloblastic
- Chapter 7: Normochromic Anemias: Biochemical, Membrane, and Miscellaneous Red Blood Cell Disorders
- Role of the Spleen in Red Blood Cell Membrane Disorders
- Hereditary Spherocytosis
- Genetics and Pathophysiology of Hereditary Spherocytosis
- Clinical Presentation in Hereditary Spherocytosis
- Laboratory Diagnosis of Hereditary Spherocytosis
- Treatment and Management of Hereditary Spherocytosis
- Hereditary Elliptocytosis
- Common Hereditary Elliptocytosis
- Southeast Asian Ovalocytosis
- Spherocytic Hereditary Elliptocytosis
- Hereditary Pyropoikilocytosis
- Hereditary Stomatocytosis and Hereditary Xerocytosis
- Glucose-6-Phosphate Dehydrogenase Deficiency
- Genetics of Glucose-6-Phosphate Dehydrogenase Deficiency
- Clinical Manifestations of Glucose-6-Phosphate Dehydrogenase Deficiency
- Acute Hemolytic Anemia
- Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency
- Pyruvate Kinase Deficiency
- Miscellaneous Red Blood Cell Disorders
- Aplastic Anemia
- Fanconi’s Anemia
- Diamond-Blackfan Anemia
- Paroxysmal Nocturnal Hemoglobinuria
- Cold Agglutinin Syndrome
- Paroxysmal Cold Hemoglobinuria
- Congenital Dyserythropoietic Anemias
- Acquired Anemias of Variable External Causes
- Chapter 8: The Normochromic Anemias Caused by Hemoglobinopathies
- General Description of Hemoglobinopathies
- Sickle Cell Anemia
- Genetics and Incidence of Sickle Cell Anemia
- Pathophysiology of Sickling Process
- Clinical Considerations for Sickle Cell Anemia
- Laboratory Diagnosis
- Sickle Cell Trait
- Hemoglobin C Disease and Trait and Hemoglobin SC
- Variant Hemoglobins
- Hemoglobin S–Beta Thalassemia
- Hemoglobin E
- Hemoglobin DPunjab and Hemoglobin GPhila
- Hemoglobin OArab
- Part III: White Blood Cell Disorders
- Chapter 9: Leukopoiesis, WBC Differential, and Lymphocyte Function
- Leukopoiesis
- Stages of Leukocyte Maturation
- Features of Cell Identification
- Lymphocyte Origin and Function
- Lymphocyte Populations
- Travel Path of Lymphocytes
- Lymphocytes and Development of Immunocompetence
- Response of Lymphocytes to Antigenic Stimulation
- Lymphocyte Cell Markers and Cluster of Differentiation
- Leukocyte Count From Complete Blood Cell Count to Differential
- Manual Differential Versus Differential Scan
- Relative Versus Absolute Values
- Chapter 10: Abnormalities of White Blood Cells: Quantitative, Qualitative, and the Lipid Storage Diseases
- Introduction to White Blood Cell Disorders
- Quantitative Changes in White Blood Cells
- Specific Terminology Relating to Quantitative White Blood Cell Changes
- Stages of White Blood Cell Phagocytosis
- Qualitative Defects of White Blood Cells
- Toxic Changes in White Blood Cells
- Human Ehrlichiosis
- Nuclear Abnormalities: Hypersegmentation
- Hereditary White Blood Cell Disorders
- May-Hegglin Anomaly
- Alder’s Anomaly
- Pelger-Huët Anomaly
- Chédiak-Higashi Syndrome
- Reactive Lymphocytosis in Common Disease States
- Other Viral Sources of Reactive Lymphocytosis
- Effect of HIV/AIDS on Hematology Parameters
- Lipid Storage Diseases
- Common Features of a Few Lipid Storage Diseases
- Bone Marrow Cells in Lipid Storage Disorders
- Bacteria and Other Unexpected White Blood Cell Changes
- Chapter 11: Acute Leukemias
- Definition of Leukemia
- Comparing Acute and Chronic Leukemia
- Leukemia History
- Acute Myeloid Leukemia
- Epidemiology
- Clinical Features
- Laboratory Features
- Classification
- Acute Leukemias of Ambiguous Lineage
- Important Acute Myeloid Leukemia Prognostic Factors
- Acute Lymphoblastic Leukemia
- Epidemiology
- Clinical Features
- Classifications
- Prognosis in Acute Lymphoblastic Leukemia
- Chapter 12: Myeloproliferative Neoplasms
- Introduction to Myeloproliferative Neoplasms
- World Health Organization Classifications
- Chronic Myeloid Leukemia BCR-ABL1+
- Pathophysiology
- Clinical Features and Symptoms
- Peripheral Blood and Bone Marrow
- Diagnosis
- Treatment
- Prognosis
- Chronic Neutrophilic Leukemia
- Chronic Eosinophilic Leukemia Not Otherwise Specified
- Polycythemia Vera
- Pathophysiology
- Clinical Features and Symptoms
- Peripheral Blood and Bone Marrow Findings
- Diagnosis
- Treatment
- Prognosis
- Primary Myelofibrosis
- Pathophysiology
- Clinical Features and Symptoms
- Peripheral Blood and Bone Marrow Findings
- Diagnosis
- Treatment
- Prognosis
- Essential Thrombocythemia
- Pathophysiology
- Clinical Features and Symptoms
- Peripheral Blood and Bone Marrow Findings
- Diagnosis
- Treatment
- Prognosis
- Mastocytosis
- Chapter 13: Lymphoproliferative Disorders and Related Plasma Cell Disorders
- Lymphoid Malignancies
- Chronic Lymphocytic Leukemia
- Prolymphocytic Leukemia
- Hairy Cell Leukemia
- Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma
- Sézary Syndrome
- Plasma Cell Disorders
- Plasma Cell Structure and Function
- Multiple Myeloma
- Waldenström’s Macroglobulinemia
- Chapter 14: The Myelodysplastic Syndromes
- Introduction to Myelodysplastic Syndromes
- Pathophysiology
- Chromosomal Abnormalities
- Common Features and Clinical Symptoms
- How to Recognize Dysplasia
- Classification of Myelodysplastic Syndromes
- Specific Features of 2016 World Health Organization Classification
- Prognostic Factors and Clinical Management
- Part IV: Hemostasis and Disorders of Coagulation
- Chapter 15: Overview of Hemostasis and Platelet Physiology
- Normal Hemostasis: Overview
- Vascular System
- Vasoconstriction
- Contribution of Endothelial Cells
- Evaluation of Endothelial Cells
- Platelets and Primary Hemostasis
- Platelet Structure and Physiology
- Platelet Function in Primary Hemostasis
- Platelet Properties
- Evaluation of Platelets
- Hemostatic Proteins and Secondary Hemostasis
- Coagulation Factors (Coagulation Cascade)
- Regulatory Inhibitors
- Hemostatic Protein Groups
- Fibrinolytic System
- Screening Tests for Evaluation of Bleeding Disorders
- Chapter 16: Quantitative and Qualitative Platelet Disorders
- Quantitative Disorders of Platelets
- Thrombocytopenia Related to Sample Integrity and Preanalytic Variables
- Thrombocytopenia Related to Decreased Production
- Thrombocytopenia Related to Altered Distribution of Platelets
- Thrombocytopenia Related to Immune Effect of Specific Drugs or Antibody Formation
- Thrombocytopenia Related to Consumption of Platelets
- Thrombocytosis
- Inherited Qualitative Disorders of Platelets
- Disorders of Adhesion
- Platelet Release Defects
- Acquired Defects of Platelet Function
- Vascular Disorders Leading to Platelet Dysfunction
- Chapter 17: Defects of Plasma Clotting Factors
- Plasma Clotting Factors and Hemophilias
- Evaluation of a Bleeding Disorder
- Treatment of Hemophilia A Patients
- Quality-of-Life Issues for Hemophilia A Patients
- Factor VIII Inhibitors
- Hemophilia B (Christmas Disease)
- Congenital Factor Deficiencies
- Congenital Factor Deficiencies With Bleeding Manifestations
- Congenital Factor Deficiencies in Which Bleeding Is Mild or Absent
- Factor XIII Deficiency
- Bleeding Secondary to a Chronic Disease Process
- Role of Vitamin K in Hemostasis
- Vitamin K Deficiency and Subsequent Treatment
- Chapter 18: Fibrinogen, Thrombin, and the Fibrinolytic System
- Overview of Fibrinogen in Clot Formation and Lysis
- Disorders of Fibrinogen
- Afibrinogenemia
- Hypofibrinogenemia
- Dysfibrinogenemia
- Multiple Roles of Thrombin in Hemostasis
- Fibrinolysis
- Clot Dissolution
- Naturally Occurring Inhibitors of Fibrinolysis
- Measurable Products of the Fibrinolytic System
- Disseminated Intravascular Coagulation
- Mechanism of Acute Disseminated Intravascular Coagulation
- Primary Fibrinolysis
- Clinical Symptoms and Laboratory Results in Acute Disseminated Intravascular Coagulation
- Treatment of Acute Disseminated Intravascular Coagulation
- Chapter 19: Introduction to Thrombosis and Anticoagulant Therapy
- Thrombophilia and Thrombosis—an Overview
- Physiologic and Pathologic Thrombosis
- Pathophysiology of Thrombosis
- Laboratory Diagnosis of Thrombotic Disorders
- Inherited Thrombotic Disorders
- Acquired Thrombotic Disorders
- The Laboratory’s Role in Diagnosing Thrombophilia
- Anticoagulant Therapy
- Antiplatelet Drugs
- Anticoagulant Drugs
- Alternative Anticoagulant Drugs
- Thrombolytic Drugs
- Part V: Hematology Automation, Flow Cell Cytometry, and Laboratory Procedures
- Chapter 20: Hematology Automation and Flow Cell Cytometry
- Hematology Automation
- Electrical Impedance
- Histograms
- Radiofrequency
- Opacity
- Scatterplot
- Optical Scatter
- VCS Technology
- Hydrodynamic Focusing
- Flow Cytometry
- Optical Platelet Counting and Flow Cytometry
- Instruments
- Data Reporting
- Beckman-Coulter Instrumentation
- Sysmex Instrumentation
- CellaVision Automated Digital Cell Morphology
- Abbott CELL-DYN Instrumentation
- Siemens Healthcare Advia Instrumentation
- Cerebrospinal Fluid Analysis on the Advia 120/2120
- Quality Assurance and Quality Control
- Coagulation Automation and Instruments
- Coagulation Automation
- Coagulation Instruments
- Flow Cytometry Instrumentation
- Principles of Operation
- Fluidics
- Optics
- Electronics
- Analysis
- Quality Control
- Applications of Flow Cytometry
- Chapter 21: Basic Procedures in a Hematology Laboratory
- Microhematocrit
- Modified Westergren Sedimentation Rate
- Manual Reticulocyte Procedure
- Peripheral Smear Procedure
- Performing a Manual Differential and Assessing Red Blood Cell Morphology
- Leukochek White Blood Cell and Platelet Manual Count
- Sickle Cell Screening Procedure
- Cerebrospinal Fluid and Body Fluid Cell Count and Differential
- Body Fluid Analysis on the Sysmex XE-5000
- Prothrombin Time and Activated Partial Thromboplastin Time: Automated Procedure
- Quantitative D-Dimer—Innovance on Sysmex CA7000
- Appendix A: Answers to Review Questions
- Appendix B: List of Abbreviations
- Glossary
- Index
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