This is completed downloadable of Fluid Test Bank for Pharmacology and the Nursing Process, 5th Edition: Linda L. Lilley
Product Details:
- ISBN-10 : 0323044867
- ISBN-13 : 978-0323044868
- Author: Linda Lilley, Julie S. Snyder
This market-leading text is known for presenting challenging content in a clear and consistent format that engages students. With an eye-catching design, full-color illustrations, and helpful, practical boxed features that highlight need-to-know information, the new edition of this bestseller continues its tradition of making pharmacology easy to learn and understand.
- A companion CD includes resources such as 450 NCLEX examination-style review questions, 26 state-of-the-art animations, and 9 IV therapy and 5 medication errors checklists.
- Study Skills Tips include practical advice on time management, note taking, study techniques, and test taking.
- Drug profiles highlight the pharmacokinetics and unique variations of individual drugs.
- Case studies and critical thinking activities test students’ knowledge and understanding.
- Medication Errors: Preventing and Responding chapter discusses specific nursing measures to prevent medication errors, possible consequences of medication errors to nurses, responses to errors, reporting and learning from mistakes, and other ethical issues.
- Patient teaching tips include key points to convey to patients, their families, and caregivers.
- Points to Remember boxes summarize major concepts in a bulleted format.
- NCLEX exam-style review questions provide a pharmacology review and add a new emphasis on prioritization.
- e-Learning activities boxes list related content and exercises on the companion CD and Evolve website.
- Key drugs are highlighted with an icon for quick identification.
- Photo Atlas of Medication Administration depicts steps in drug administration for various routes.
- Tear-out IV incompatibility chart provides a convenient portable reference.
- Life Span Considerations boxes highlight important age-related implications for pediatric and elderly patients.
- A new focus on prioritization identifies key nursing information and helps in preparation for the NCLEX® examination.
- Preventing Medication Errors boxes reinforce concepts introduced in the medication errors chapter and relate them to specific common errors that occur in clinical practice.
- Evidence-Based Practice boxes summarize current research relevant to safe and effective drug therapy.
- Laboratory Values Related to Drug Therapy boxes highlight the therapeutic levels of various drugs.
- Expanded bioterrorism content now includes chemical agents such as ricin.
- Increased focus on drug class provides a “big picture” knowledge of how various drugs work in the body.
- Expanded cultural content covers today’s increasingly diverse patient population.
- Pharmacokinetic Bridge to the Nursing Process sections apply key pharmacokinetics information to nursing practice.
Table of Content:
- PART 1 Pharmacology Basics
- Pharmacology Basics
- STUDY SKILLS TIPS
- INTRODUCTION TO STUDY SKILLS CONCEPTS
- PURR
- Prepare
- On-the-Run Action.
- Understand
- Rehearse
- How to Rehearse.
- When to Rehearse.
- Review
- How to Review.
- Frequency of Review.
- Techniques for Rehearsal and Review.
- PHARMACOLOGY BASICS
- Prepare
- Chapter 1 Objectives
- Vocabulary Development
- CHAPTER 1 The Nursing Process and Drug Therapy
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley/)
- Glossary
- OVERVIEW OF THE NURSING PROCESS
- Box 1-1 Sample Nursing Care Plan Related to Drug Therapy and the Nursing Process
- Assessment
- Objective Data
- Subjective Data
- Nursing Diagnoses
- Planning: Goals and Outcome Criteria
- Implementation
- Evaluation
- ASSESSMENT
- Analysis of Data
- NURSING DIAGNOSES
- Box 1-2 A Brief Look at NANDA and the Nursing Process
- PLANNING
- Box 1-3 Selected NANDA-Approved Nursing Diagnoses
- Goals and Outcome Criteria
- IMPLEMENTATION
- Right Drug
- Right Dose
- Right Time
- Preventing Medication Errors
- Right Dose?
- Table 1-1 Conversion of Standard Time to Military Time
- Right Route
- Right Patient
- System Analysis
- Medication Errors
- EVALUATION
- Legal and Ethical Principles
- Charting Don’ts
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 2 Pharmacologic Principles
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- OVERVIEW
- FIGURE 2-1 Chemical structure of the common analgesic ibuprofen and the chemical, generic, and trade names for the drug.
- FIGURE 2-2 Phases of drug activity. (From McKenry LM, Tessier E, Hogan M: Mosby’s pharmacology in nursing, ed 22, St Louis, 2006, Mosby.)
- PHARMACEUTICS
- Table 2-1 Drug Absorption of Various Oral Preparations
- Table 2-2 Dosage Forms
- PHARMACOKINETICS
- Pharmacokinetic Profiles
- Absorption
- Overview of Pharmacokinetics: Oral Administration
- Drug Movement Through the Body
- Preventing Medication Errors
- Does IV = PO?
- Enteral
- FIGURE 2-3 First-pass effect is the metabolism of a drug by the liver before its systemic availability.
- Impact of Surface Area
- Sublingual and Buccal
- Table 2-3 Routes of Administration and Related Nursing Considerations
- Box 2-1 Drugs to Be Taken on an Empty Stomach and Drugs to Be Taken with Food
- Parenteral
- Subcutaneous, Intradermal, and Intramuscular
- Topical
- Box 2-2 Drug Routes and First-Pass Effects
- First-Pass Routes
- Non–First-Pass Routes
- Transdermal
- Inhaled
- Distribution
- FIGURE 2-4 Drug transport in the body. GI, Gastrointestinal. (From McKenry LM, Salerno E: Mosby’s pharmacology in nursing, ed 19, St Louis, 1995, Mosby.)
- Distribution of Fat-Soluble vs. Water-Soluble Drugs
- Metabolism
- Table 2-4 Mechanisms of Biotransformation
- Table 2-5 Common Liver Cytochrome P-450 Enzymes and Corresponding Drug Substrates
- Cytochrome P-450 Drug Metabolism
- Table 2-6 Examples of Conditions and Drugs That Affect Drug Metabolism
- Excretion
- FIGURE 2-5 Renal drug excretion. The primary processes involved in drug excretion and the approximate location where these processes take place in the kidney are illustrated. GFR, Glomerular filtration rate.
- Half-Life
- Time to Steady State
- Time to Steady State: Starting and Stopping Drug
- Table 2-7 Example of Drug Half-Life Viewed from Different Perspectives
- FIGURE 2-6 Characteristics of drug effect and relationship to the therapeutic window. (From McKenry LM, Tessier E, Hogan M: Mosby’s pharmacology in nursing, ed 22, St Louis, 2006, Mosby.)
- Onset, Peak, and Duration
- PHARMACODYNAMICS
- FIGURE 2-7 A, Drugs act by forming a chemical bond with specific receptor sites, similar to a key and lock. B, The better the “fit,” the better the response. Drugs with complete attachment and response are called agonists. C, Drugs that attach but do not elicit a response are called antagonists. D, Drugs that attach, elicit some response, and also block other responses are called partial agonists or agonist-antagonists. (From Clayton BD, Stock YN: Basic pharmacology for nurses, ed 13, St Louis, 2004, Mosby.)
- Table 2-8 Drug-Receptor Interactions
- Agonists/Antagonists
- Mechanism of Action
- Receptor Interactions
- Receptor Interaction
- Enzyme Interactions
- Nonselective Interactions
- PHARMACOTHERAPEUTICS
- Acute Therapy
- Maintenance Therapy
- Supplemental Therapy
- Palliative Therapy
- Supportive Therapy
- Prophylactic Therapy and Empiric Therapy
- Monitoring
- Therapeutic Index
- Drug Concentration
- Patient’s Condition
- Tolerance and Dependence
- Interactions
- Table 2-9 Examples of Drug Interactions and Their Effects on Pharmacokinetics
- Adverse Drug Events
- Other Drug Effects
- Box 2-3 Drugs to Avoid in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency
- Cultural Implications
- Glucose-6-Phosphate Dehydrogenase Deficiency
- Box 2-4 Exogenous Causes of Cancer
- PHARMACOGNOSY
- TOXICOLOGY
- CASE STUDY
- Pharmacokinetics
- Table 2-10 Common Causes of Poisoning and Antidotes
- CONCLUSION
- Nursing, Medical, and Pharmacology Domains
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 3 Life Span Considerations
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- DRUG THERAPY DURING PREGNANCY
- Table 3-1 Pregnancy Safety Categories
- Passive Diffusion
- DRUG THERAPY DURING BREAST-FEEDING
- CONSIDERATIONS FOR NEONATAL AND PEDIATRIC PATIENTS
- Physiology and Pharmacokinetics
- Pharmacodynamics
- Dosage Calculations for Pediatric Patients
- Table 3-2 Classification of Young Patients
- Life Span Considerations: The Pediatric Patient
- Pharmacokinetic Changes in the Neonate and Pediatric Patient
- Absorption
- Distribution
- Metabolism
- Excretion
- FIGURE 3-1 West nomogram for infants and children. S.A., Surface area. (Modified from data by E. Boyd and C. D. West. In Behrman RE, Kliegman RM, Jensen HB: Nelson textbook of pediatrics, ed 17, Philadelphia, 2004, Saunders.)
- CONSIDERATIONS FOR ELDERLY PATIENTS
- Lifespan Considerations: The Elderly Patient
- Percentage of Population over 65 Years of Age
- Polypharmacy and Drug Use
- Life Span Considerations: The Elderly Patient
- Alzheimer’s Disease
- Physiologic Changes
- Table 3-3 Physiologic Changes in the Elderly Patient
- Pharmacokinetics
- Absorption
- Life Span Considerations: The Elderly Patient
- Pharmacokinetic Changes
- Absorption
- Distribution
- Metabolism
- Excretion
- Distribution
- Metabolism
- Excretion
- Problematic Medications for the Elderly
- Table 3-4 Problematic Medications and Conditions to Consider for the Elderly Patient
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- EVIDENCE-BASED PRACTICE
- The Beers Criteria for Drug Use in the Elderly
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Life Span Considerations: The Pediatric Patient
- Age-Related Considerations for Medication Administration from Infancy to Adolescence
- General Interventions
- Infants
- Toddlers
- Preschoolers
- School-Aged Children
- Adolescents
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 4 Cultural, Legal, and Ethical Considerations
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- Table 4-1 Summary of Major U.S. Drug Legislation
- Table 4-2 Controlled Substances: Schedule Categories
- U.S. DRUG LEGISLATION
- Table 4-3 Controlled Substances: Categories, Dispensing Restrictions, and Examples
- NEW DRUG DEVELOPMENT
- Investigational New Drug Application
- Informed Consent
- U.S. Food and Drug Administration Drug Approval Process
- Preclinical Investigational Drug Studies
- Four Clinical Phases of Investigational Drug Studies
- Phase I
- Phase II
- Phase III
- Phase IV
- LEGAL AND ETHICAL PRINCIPLES
- Use of Placebos
- Expedited Drug Approval
- LEGAL ISSUES AND NURSING IMPLICATIONS
- LEGAL AND ETHICAL PRINCIPLES
- Ethical Terms Related to Nursing Practice
- Box 4-1 American Nurses Association Code of Ethics for Nurses
- Provisions of the Code
- Ethical Practice
- Box 4-2 Legal-Ethical Considerations in Nursing Practice: The ICN Code of Ethics for Nurses
- CULTURAL CONSIDERATIONS
- Influence of Ethnicity and Genetics
- CULTURAL IMPLICATIONS
- Cultural Terms Related to Nursing Practice
- CULTURAL IMPLICATIONS
- Common Practices of Selected Cultural Groups
- Table 4-4 Examples of Varying Drug Responses in Different Racial or Ethnic Groups
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Maintaining Health
- Protecting Health
- Restoring Health
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 5 Medication Errors: Preventing and Responding
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- INTRODUCTION
- General Impact of Errors on Patients
- Medication Errors
- FIGURE 5-1 Diagram illustrating the various classes and subclasses of adverse drug events. ADRs, Adverse drug reactions; ARs, allergic reactions; IRs, idiosyncratic reactions; SEs, side effects.
- Box 5-1 Common Classes of Medications Involved in Serious Errors
- PSYCHOSOCIAL ISSUES THAT CONTRIBUTE TO ERRORS
- Organizational Issues
- PREVENTING MEDICATION ERRORS
- Selected Examples of Commonly Confused Drug Names
- Educational System Issues and Their Potential Impact on Medication Errors
- Medication Errors and Related Sociologic Factors
- PREVENTING AND RESPONDING TO ERRORS
- Reporting and Responding to Medication Errors
- Medication Reconciliation
- OTHER ETHICAL ISSUES
- Notification of Patients Regarding Errors
- Whistle-Blowing
- NURSING MEASURES TO PREVENT MEDICATION ERRORS
- LEGAL AND ETHICAL PRINCIPLES
- Use of Abbreviations
- Possible Consequences of Medication Errors for Nurses
- Life Span Considerations: The Elderly Patient
- Medication Errors
- Life Span Considerations: The Pediatric Patient
- Medication Errors
- POLITICAL ACTION
- An Ounce of Prevention: Nurse Advocacy for Safer Health Care Organizations
- CASE STUDY
- Medication Errors
- SUMMARY
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 6 Patient Education and Drug Therapy
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- ASSESSMENT OF LEARNING NEEDS RELATED TO DRUG THERAPY
- Box 6-1 Erikson’s Stages of Development
- CULTURAL IMPLICATIONS
- Patient Education
- NURSING DIAGNOSES RELATED TO LEARNING NEEDS AND DRUG THERAPY
- Patient Noncompliance
- PLANNING RELATED TO LEARNING NEEDS AND DRUG THERAPY
- Table 6-1 Educational Strategies to Address Common Changes Related to Aging That May Influence Learning
- IMPLEMENTATION RELATED TO PATIENT EDUCATION AND DRUG THERAPY
- EVIDENCE-BASED PRACTICE
- The Impact of Better Education of Nurses on Patient Outcomes
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Box 6-2 General Teaching and Learning Principles
- LEGAL AND ETHICAL PRINCIPLES
- Discharge Teaching
- EVALUATION OF PATIENT LEARNING RELATED TO DRUG THERAPY
- SUMMARY
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 7 Over-the-Counter Drugs and Herbal and Dietary Supplements
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- OVER-THE-COUNTER DRUGS
- Box 7-1 Timetable of Major Legal Events Affecting U.S. Drug Use
- Box 7-2 Criteria for Over-the-Counter Status
- Indication for Use
- Safety Profile
- Practicality for Over-the-Counter Use
- Box 7-3 Reclassified Over-the-Counter Products
- Analgesics
- Histamine Blockers
- H1 Receptors
- H2 Receptors
- Mast Cell Stabilizers
- Smoking Deterrents
- Topical Medications
- FIGURE 7-1 Example of an over-the-counter drug label.
- Table 7-1 Common Over-the-Counter (OTC) Drugs
- HERBALS AND DIETARY SUPPLEMENTS
- History
- Table 7-2 Conventional Medicines Derived from Plants
- Consumer Use of Dietary Supplements
- Safety
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Selected Herbs and Dietary Supplements and Their Possible Drug Interactions
- Epidemiology
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Over-the-Counter Drugs
- Herbal Products and Dietary Supplements
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CULTURAL IMPLICATIONS
- Drug Responses and Cultural Factors
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 8 Substance Abuse
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- Box 8-1 Categories of Abused Substances
- Major Categories
- Individual Drugs
- OPIOIDS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Management of Withdrawal, Toxicity, and Overdose
- Box 8-2 Signs and Symptoms of Opioid Withdrawal
- Peak Period
- Duration
- Signs
- Symptoms
- Box 8-3 Medications for Treatment of Opioid Withdrawal
- Clonidine (Catapres) Substitution
- Methadone Substitution
- STIMULANTS
- Table 8-1 Various Forms of Amphetamine and Cocaine with Street Names
- Life Span Considerations: The Pediatric Patient
- Substance Abuse
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Management of Withdrawal, Toxicity, and Overdose
- Box 8-4 Signs and Symptoms of Stimulant Withdrawal
- Peak Period
- Duration
- Signs
- Symptoms
- DEPRESSANTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Management of Withdrawal, Toxicity, and Overdose
- Box 8-5 Signs, Symptoms, and Treatment of Depressant Withdrawal
- Peak Period
- Duration
- Signs
- Symptoms
- Treatment of Benzodiazepine Withdrawal
- Treatment of Barbiturate Withdrawal
- Table 8-2 Barbiturate Equivalencies
- ALCOHOL
- Mechanism of Action and Drug Effects
- Indications
- Adverse Effects
- Management of Withdrawal, Toxicity, and Overdose
- Box 8-6 Signs, Symptoms, and Treatment of Ethanol Withdrawal
- Mild Withdrawal
- Signs and Symptoms
- Treatment
- Moderate Withdrawal
- Signs and Symptoms
- Treatment
- Severe Withdrawal (Delirium Tremens)*
- Signs and Symptoms
- Treatment
- Table 8-3 Acetaldehyde Syndrome
- NICOTINE
- Mechanism of Action and Drug Effects
- Indications
- Adverse Effects
- Management of Withdrawal, Toxicity, and Overdose
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Table 8-4 Nicotine Withdrawal Therapies
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Life Span Considerations: The Elderly Patient
- Substance Abuse
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 9 Photo Atlas of Drug Administration
- PREPARING FOR DRUG ADMINISTRATION
- ENTERAL DRUGS
- Administering Oral Drugs
- Oral Medications
- FIGURE 9-1 Using a computer-dispensing system to remove unit-dose medication.
- FIGURE 9-2 Checking the medication against the order on the medication administration record.
- FIGURE 9-3 Always check the patient’s identification and allergies before giving medications.
- Box 9-1 Standard Precautions
- Sublingual and Buccal Medications
- FIGURE 9-4 Some medications require special assessment before giving, such as taking an apical pulse.
- FIGURE 9-5 Crushing tablets with a mortar and pestle.
- FIGURE 9-6 Enteric-coated tablets and long-acting medications should not be crushed.
- FIGURE 9-7 Giving oral medications.
- FIGURE 9-8 Proper placement of a sublingual tablet.
- FIGURE 9-9 Example of a medication administration record (MAR).
- Liquid Medications
- FIGURE 9-10 Liquid medication in a unit-dose package. B, Liquid measured into a medicine cup from a multidose container. C, Liquid medicine in an oral-dosing syringe.
- Oral Medications and Infants
- FIGURE 9-11 Measuring liquid medication.
- FIGURE 9-12 Administering oral liquid medication to an infant.
- Administering Drugs Through a Nasogastric or Gastrostomy Tube
- FIGURE 9-13 Elevate the head of the bed before administering medications through a nasogastric tube.
- FIGURE 9-14 Medications given through gastric tubes should be administered separately. Dilute crushed pills in 15 to 30 mL of water before administration.
- FIGURE 9-15 Pour liquid medication into the syringe, then unclamp the tubing and allow it to flow in by gravity.
- Administering Rectal Drugs
- FIGURE 9-16 Lubricate the suppository with a water-soluble lubricant.
- FIGURE 9-17 Inserting a rectal suppository.
- PARENTERAL DRUGS
- Preparing for Parenteral Drug Administration
- FIGURE 9-18 NEVER RECAP A USED NEEDLE! Always dispose of uncapped needles in the appropriate sharps container. Refer to Box 9-1 for Standard Precautions.
- FIGURE 9-19 An UNUSED needle may need to be recapped before the medication is given to the patient. The “scoop method” is one way to recap an unused needle safely. Be sure not to touch the needle to the countertop or to the outside of the needle cap.
- FIGURES 9-20 AND 9-21 There are several types of needlestick prevention syringes. This example (Figure 9-20) has a guard over the unused syringe. After the injection, the nurse pulls the guard up over the needle until it locks into place (Figure 9-20).
- FIGURE 9-22 The parts of a syringe and hypodermic needle.
- FIGURE 9-23 Close-up view of the bevel of a needle.
- FIGURE 9-24 Be sure to choose the correct size and type of syringe for the drug ordered.
- FIGURE 9-25 Needles come in various gauges and lengths. The larger the gauge, the smaller the needle. Be sure to choose the correct needle—gauge and length—for the type of injection ordered.
- FIGURES 9-26 AND 9-27 Some medications come in a prefilled, sterile medication cartridge. Figures 9-26 and 9-27 show the Carpuject prefilled cartridge and syringe system. Follow the manufacturer’s instructions for assembling prefilled syringes. After use, the syringe is disposed of in a sharps container; the cartridge is reusable.
- Inserting a Pre-Filled Cartridge with Needle into the Carpuject Syringe
- FIGURE 9-28 Ampules containing medications come in various sizes. The ampules must be broken carefully to withdraw the medication.
- FIGURE 9-29 A filter needle should be used when withdrawing medication from an ampule. Filter needles help to remove tiny glass particles that may result from the ampule breakage. DO NOT USE A FILTER NEEDLE for injection into a patient! Some facilities may require the use of a filter needle to withdraw medications from a vial.
- Removing Medications from Ampules
- Drawing up Medication from an Ampule
- FIGURE 9-30 Tapping an ampule to move the fluid below the neck.
- FIGURES 9-31 AND 9-32 Breaking an ampule.
- FIGURE 9-33 Using a filter needle to withdraw medication from an ampule.
- Removing Medications from Vials
- Withdrawing Medication from a Vial
- Mixing Two Medications in One Syringe from Two Vials
- Mixing Two Medications in One Syringe from One Vial and One Ampule
- Mixing Two Medications in One Pre-Filled Cartridge and a Vial
- Mix-O-Vials
- FIGURE 9-34 Insert air into a vial before withdrawing medication (needleless system shown).
- FIGURE 9-35 Withdrawing medication from a vial (needleless system shown).
- FIGURE 9-36 Using a needle and syringe to remove medication from a vial.
- Injections Overview
- Needle Insertion Angles for Intramuscular, Subcutaneous, and Intradermal Injections
- FIGURE 9-37 Various needle angles.
- Z-Track Method
- FIGURES 9-38 AND 9-39 The Z-track method for intramuscular injections.
- Air-Lock Technique
- FIGURE 9-40 Air-lock technique for intramuscular injections.
- Intradermal Injection
- FIGURES 9-41 AND 9-42 Intradermal injection.
- Subcutaneous Injections
- FIGURE 9-43 Potential sites for subcutaneous injections.
- Insulin Syringes
- FIGURE 9-44 Before giving an injection, cleanse the skin with an alcohol or antiseptic swab.
- FIGURE 9-45 Giving a subcutaneous injection at a 90-degree angle.
- FIGURE 9-46 When giving a subcutaneous injection in the abdomen, be sure to choose a site at least 2 inches away from the umbilicus.
- FIGURE 9-47 Insulin syringes are available in 100-unit and 50-unit calibrations.
- FIGURE 9-48 A variety of devices are available for insulin injections.
- FIGURE 9-49 Mixing two types of insulin in the same syringe.
- Intramuscular Injections
- FIGURE 9-50 Finding landmarks for a ventrogluteal injection.
- Ventrogluteal Site
- FIGURES 9-51 AND 9-52 Ventrogluteal intramuscular injection.
- Vastus Lateralis Site
- FIGURE 9-53 Vastus lateralis intramuscular injection in an infant.
- FIGURES 9-54, 9-55, AND 9-56 Vastus lateralis intramuscular injection.
- Dorsogluteal Site
- FIGURES 9-57, 9-58, AND 9-59 Dorsogluteal intramuscular injection.
- Deltoid Site
- FIGURES 9-60, 9-61, AND 9-62 Deltoid intramuscular injection.
- Preparing Intravenous Medications
- FIGURE 9-63 Two types of intravenous piggyback (IVPB) medication delivery systems. These IVPB medications must be activated before administration to the patient.
- FIGURE 9-64 Activating an intravenous piggyback infusion bag (step 1).
- FIGURE 9-65 Activating an intravenous piggyback infusion bag (step 2).
- FIGURE 9-66 Activating an intravenous piggyback infusion bag (step 3).
- FIGURES 9-67, 9-68, AND 9-69 Adding a medication to an intravenous infusion bag with a needle and syringe.
- FIGURE 9-70 Mix the medication thoroughly before infusing.
- FIGURE 9-71 Label the intravenous infusion bag when medication has been added.
- Infusions of Intravenous Piggyback Medications
- FIGURE 9-72 Infusing an intravenous piggyback medication with a gravity primary intravenous infusion.
- FIGURE 9-73 Infusing an intravenous piggyback medication with the primary intravenous infusion on an electronic infusion pump.
- FIGURE 9-74 Adding a medication to a volume-controlled administration set.
- FIGURE 9-75 Instructing the patient on the use of a patient-controlled analgesia pump.
- Intravenous Push Medications
- Intravenous Push Medications Through an Intravenous Lock
- Intravenous Push Medications Through an Existing Infusion
- After Injection of an Intravenous Push Medication
- FIGURE 9-76 Cleanse the port before attaching the syringe.
- FIGURE 9-77 Attaching the syringe to the intravenous lock.
- FIGURE 9-78 Slowly inject the intravenous push medication through the intravenous lock; use a watch to time the injection.
- FIGURE 9-79 When giving an intravenous push medication through an intravenous line, pinch the tubing just above the injection port.
- TOPICAL DRUGS
- Administering Eye Medications
- Eyedrops
- FIGURE 9-80 Cleanse the eye, washing from the inner to outer canthus, before giving eye medications.
- Eye Ointment
- After Instillation of Eye Medications
- FIGURE 9-81 Insert the eyedrop into the lower conjunctival sac.
- FIGURE 9-82 Applying eye ointment.
- FIGURE 9-83 Applying gentle pressure against the nasolacrimal duct after giving eye medications.
- Administering Eardrops
- FIGURE 9-84 For adults, pull the pinna up and back.
- FIGURE 9-85 For infants and children younger than 3 years of age, pull the pinna down and back.
- Administering Nasal Medications
- Nasal Drops
- FIGURE 9-86 Nasal medications may come in various delivery forms.
- FIGURE 9-87 Administering nose drops.
- Nasal Spray
- After Administration of Nasal Medicines
- FIGURE 9-88 Before self-administering the nasal spray, the patient should occlude the other nostril.
- Administering Inhaled Drugs
- Metered-Dose Inhalers
- FIGURE 9-89 A, Metered-dose inhaler (MDI). B, Automated, or breath-activated, MDI. C, Dry powder inhaler that delivers powdered medication.
- FIGURE 9-90 Using a metered-dose inhaler without a spacer.
- FIGURE 9-91 Instructing the patient on how to use a spacer device.
- FIGURE 9-92 Using a spacer device with a metered-dose inhaler.
- Small-Volume Nebulizers
- FIGURE 9-93 Adding medication to the nebulizer cup.
- FIGURE 9-94 Administering a small-volume nebulizer treatment.
- Administering Medications to the Skin
- Lotions, Creams, Ointments, and Powders
- FIGURE 9-95 Use gloves to apply topical skin preparations.
- Transdermal Patches
- After Administration of Topical Skin Preparations
- FIGURE 9-96 Spread the lotion on the skin with long, smooth, gentle strokes.
- FIGURE 9-97 Measure nitroglycerin ointment carefully before application.
- FIGURE 9-98 Opening a transdermal patch medication.
- FIGURE 9-99 Ensure that the edges of the transdermal patch are secure after applying.
- Administering Vaginal Medications
- Creams, Foams, or Gels Applied with an Applicator
- FIGURE 9-100 Vaginal suppositories (right) are larger and more oval than rectal suppositories (left).
- FIGURE 9-101 Vaginal cream and suppository, with applicators.
- Suppositories
- FIGURE 9-102 Administering vaginal cream with an applicator.
- FIGURE 9-103 Administering a vaginal suppository.
- ILLUSTRATION CREDITS
- PART 2 Drugs Affecting the Central Nervous System
- Drugs Affecting the Central Nervous System
- STUDY SKILLS TIPS
- VOCABULARY
- TEXT NOTATION
- LANGUAGE CONVENTIONS
- CHAPTER 10 Analgesic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- PHYSIOLOGY AND PSYCHOLOGY OF PAIN
- CULTURAL IMPLICATIONS
- The Patient Experiencing Pain
- Table 10-1 Conditions That Alter Pain Threshold
- Table 10-2 Acute Versus Chronic Pain
- Table 10-3 A and C Nerve Fibers
- FIGURE 10-1 Gate theory of pain transmission. CNS, Central nervous system.
- Treatment of Pain in Special Situations
- Box 10-1 Potential Opioid Adverse Effects and Their Management
- Constipation
- Nausea and Vomiting
- Sedation and Mental Clouding
- Respiratory Depression
- Subacute Overdose
- Other Opioid Adverse Effects
- OPIOID DRUGS
- Chemical Structure
- Mechanism of Action and Drug Effects
- Indications
- Table 10-4 Chemical Classification of Opioids
- Table 10-5 Opioid Receptors and Their Characteristics
- CASE STUDY
- Opioid Administration
- PREVENTING MEDICATION ERRORS
- Fentanyl Transdermal Patches
- Contraindications
- Adverse Effects
- Table 10-6 Opioid-Induced Adverse Effects by Body System
- LEGAL AND ETHICAL PRINCIPLES
- The Impact of Nursing Assessment on Medication Administration–Related Errors
- Table 10-7 Opioid Antagonists (Reversal Drugs)
- Toxicity and Management of Overdose
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- ▸ morphine sulfate
- DOSAGES
- Selected Analgesic Drugs and Related Drugs
- Pharmacokinetics
- ▸ codeine sulfate
- Pharmacokinetics
- ▸ fentanyl
- Table 10-8 Equianalgesic Opioid Potencies (Based on Morphine 10 mg Intramuscularly and 30 mg Orally)
- Table 10-9 Transdermal Fentanyl Dosages
- Pharmacokinetics
- ▸ meperidine hydrochloride
- Pharmacokinetics
- ▸ methadone hydrochloride
- Pharmacokinetics
- ▸ oxycodone hydrochloride
- Pharmacokinetics (Immediate Release)
- Opioids and Agonists-Antagonists
- Partial Opioid Agonists
- Opioid Antagonists
- ▸ naloxone hydrochloride
- Pharmacokinetics
- ▸ naltrexone hydrochloride
- Pharmacokinetics
- NONOPIOID ANALGESICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Drug Profiles
- Nonopioid Analgesics
- ▸ acetaminophen
- Pharmacokinetics
- tramadol hydrochloride
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Box 10-2 Assessment of Pain
- EVIDENCE-BASED PRACTICE
- Strategies of Pain Assessment Used by Nurses on Surgical Units
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Life Span Considerations: The Pediatric Patient
- Opioid Use
- Life Span Considerations: The Elderly Patient
- Opioid Use
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Box 10-3 Nonpharmacologic Treatment Options for Pain
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Feverfew (Chrysanthemum parthenium)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- Table 10-10 Opioid Administration Guidelines
- Table 10-11 Drugs Not Recommended for Treatment of Cancer Pain
- CASE STUDY
- Pain Management in Terminal Illness
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 11 General and Local Anesthetics
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- GENERAL ANESTHETICS
- Box 11-1 General Anesthesia: A Historical Perspective
- Table 11-1 Inhaled General Anesthetics
- Mechanism of Action and Drug Effects
- Table 11-2 General Anesthetic Drugs
- Table 11-3 Adjunctive Anesthetic Drugs
- Life Span Considerations: The Elderly Patient
- Anesthesia
- Indications
- Contraindications
- Adverse Effects
- Table 11-4 Effects of Inhaled and Intravenous General Anesthetics
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- enflurane
- DOSAGES
- Selected General Anesthetic Drugs
- Life Span Considerations: The Pediatric Patient
- Anesthesia
- halothane
- isoflurane
- methoxyflurane
- nitrous oxide
- ▸ propofol
- sevoflurane
- LOCAL ANESTHETICS
- Table 11-5 Topical Anesthetics
- Box 11-2 Types of Local Anesthesia
- Central
- Peripheral
- Mechanism of Action and Drug Effects
- Table 11-6 Selected Parenteral Anesthetic Drugs*
- Indications
- Contraindications
- Adverse Effects
- Box 11-3 Chemical Groups of Local Anesthetics
- Ester Type
- Amide Type
- Toxicity and Management of Overdose
- Interactions
- Dosages
- DOSAGES
- Local Anesthetic Drug
- Drug Profiles
- ▸ lidocaine
- NEUROMUSCULAR BLOCKING DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Table 11-7 Effects of Ganglionic Blockade by Neuromuscular Blocking Drugs
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- PREVENTING MEDICATION ERRORS
- Neuromuscular Blocking Drugs
- Box 11-4 Conditions That Predispose Patients to Toxic Effects from Neuromuscular Blocking Drugs
- Box 11-5 Conditions That Oppose the Effects of Neuromuscular Blocking Drugs
- Box 11-6 Drugs That Interact with Neuromuscular Blocking Drugs
- Additive Effects
- Opposing Effects
- Interactions
- Dosages
- Drug Profiles
- Depolarizing Neuromuscular Blocking Drugs
- ▸ succinylcholine
- Pharmacokinetics
- Nondepolarizing Neuromuscular Blocking Drugs
- pancuronium
- DOSAGES
- Selected Neuromuscular Blocking Drugs
- Table 11-8 Classification of Neuromuscular Blocking Drugs
- Pharmacokinetics
- ▸ vecuronium
- Pharmacokinetics
- MODERATE SEDATION
- PHARMACOKINETIC BRIDGE to Nursing Practice
- Life Span Considerations: The Pediatric Patient
- Moderate or Conscious Anesthesia
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Possible Effects of Popular Herbal Products When Combined with Anesthetics
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Box 11-7 Moderate or Conscious Sedation: What to Expect
- ♦ EVALUATION
- Patient Teaching Tips
- General Anesthesia
- Local Anesthesia
- Miscellaneous
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 12 Central Nervous System Depressants and Muscle Relaxants
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- SLEEP
- Table 12-1 Sedative-Hypnotic Drugs: Points of Interest
- BARBITURATES
- Mechanism of Action and Drug Effects
- Table 12-2 Stages of Sleep
- Table 12-3 Barbiturates: Onset and Duration
- CULTURAL IMPLICATIONS
- Sedatives-Hypnotics
- Indications
- Contraindications
- Adverse Effects
- Table 12-4 Barbiturates: Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- DOSAGES
- Selected Barbiturates
- Table 12-5 Barbiturates: Controlled Substance Schedule
- pentobarbital
- Pharmacokinetics
- phenobarbital
- Pharmacokinetics
- secobarbital
- Pharmacokinetics
- BENZODIAZEPINES
- Mechanism of Action and Drug Effects
- Table 12-6 Sedative-Hypnotic Benzodiazepines
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Table 12-7 Flumazenil Treatment Regimen
- Table 12-8 Benzodiazepines: Drug Interactions
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- estazolam
- DOSAGES
- Benzodiazepines: Selected Hypnotic Drugs
- Pharmacokinetics
- flurazepam
- Pharmacokinetics
- quazepam
- Pharmacokinetics
- ▸ temazepam
- Pharmacokinetics
- triazolam
- Pharmacokinetics
- ▸ zaleplon
- Pharmacokinetics
- ▸ zolpidem
- Pharmacokinetics
- MUSCLE RELAXANTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- ▸ baclofen
- Pharmacokinetics
- ▸ cyclobenzaprine
- Pharmacokinetics
- dantrolene
- DOSAGES
- Selected Muscle Relaxants
- Pharmacokinetics
- MISCELLANEOUS DRUGS
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Kava (Piper methysticum)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Valerian (Valeriana officinalis)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ♦ EVALUATION
- Patient Teaching Tips
- Box 12-1 Sleep Diaries and Non-Pharmacologic Treatment of Sleep Disorders
- Information for a Sleep Diary
- Nonpharmacologic Sleep Interventions
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 13 Antiepileptic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- EPILEPSY
- Box 13-1 International Classification of Seizures
- Partial Seizures
- Description
- Simple Seizures
- Complex Seizures
- Generalized Seizures
- Description
- ANTIEPILEPTIC DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Table 13-1 Antiepileptic Drugs of Choice
- Table 13-2 Antiepileptic Drugs Used for Treatment of Status Epilepticus
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Table 13-3 Adverse Effects of Selected Antiepileptic Drugs
- Barbiturates
- ▸ phenobarbital
- Table 13-4 Drug Interactions of Selected Antiepileptic Drugs
- Table 13-5 Therapeutic Plasma Levels of NTI Antiepileptic Drugs
- Table 13-6 Antiepileptic Drugs: FDA Pregnancy Risk Classification
- Pharmacokinetics
- DOSAGES
- Selected Antiepileptic Drugs
- Life Span Considerations: The Pediatric Patient
- AEDs
- Hydantoins
- ▸ phenytoin
- Table 13-7 Phenytoin Sodium Versus Fosphenytoin Sodium
- Pharmacokinetics
- ▸ valproic acid
- Pharmacokinetics
- Iminostilbenes
- ▸ carbamazepine
- Pharmacokinetics
- oxcarbazepine
- Pharmacokinetics
- Miscellaneous Drugs
- ▸ gabapentin
- Pharmacokinetics
- lamotrigine
- Pharmacokinetics
- levetiracetam
- Pharmacokinetics
- tiagabine
- Pharmacokinetics
- topiramate
- Pharmacokinetics
- zonisamide
- Pharmacokinetics
- pregabalin
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- Implementation
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 14 Antiparkinsonian Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- PARKINSON’S DISEASE
- FIGURE 14-1 The neurotransmitter abnormality of Parkinson’s disease.
- Table 14-1 Classic Parkinsonian Symptom
- Table 14-2 Antiparkinsonian Drugs
- SELECTIVE MONOAMINE OXIDASE INHIBITOR THERAPY
- Mechanism of Action and Drug Effects
- Table 14-3 Selegiline: Adverse Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- PREVENTING MEDICATION ERRORS
- Look-Alike Drugs: Selegiline and Salagen
- Dosage
- Drug Profiles
- ▸ selegiline
- Pharmacokinetics
- DOPAMINERGIC THERAPY
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 14-4 Dopaminergic Drugs: Adverse Effects
- Dosages
- Drug Profiles
- levodopa
- Pharmacokinetics
- ▸ levodopa-carbidopa
- Pharmacokinetics
- amantadine
- Pharmacokinetics
- Dopamine Agonists
- Dosages
- Selegiline and Selected Dopaminergic Drugs
- bromocriptine and pergolide
- Pharmacokinetics (bromocriptine)
- Pharmacokinetics (pergolide)
- ▸ ropinirole
- Pharmacokinetics
- COMT Inhibitors
- entacapone
- Pharmacokinetics
- ANTICHOLINERGIC THERAPY
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 14-5 Anticholinergic Drugs: Adverse Effects
- Dosages
- Drug Profiles
- ▸ benztropine mesylate
- Pharmacokinetics
- Dosages
- Selected Anticholinergic Drugs
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Life Span Considerations: The Elderly Patient
- Antiparkinsonian Drugs
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 15 Psychotherapeutic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- CULTURAL IMPLICATIONS
- Psychotherapeutic Drugs
- OVERVIEW OF MENTAL ILLNESS
- ANTIANXIETY DRUGS
- Mechanism of Action and Drug Effects
- Table 15-1 Various Anxiety Disorders: Drugs of Choice
- Indications
- Table 15-2 Benzodiazepines: Approved Indications
- Contraindications
- Adverse Effects
- Table 15-3 Benzodiazepines: Common Adverse Effects
- Toxicity and Management of Overdose
- Box 15-1 Flumazenil Treatment Regimen
- Recommended Regimen
- Duration of Action
- Interactions
- Dosages
- Drug Profiles
- Benzodiazepines
- ▸ alprazolam
- Pharmacokinetics
- ▸ chlordiazepoxide
- Pharmacokinetics
- ▸ diazepam
- Pharmacokinetics
- ▸ lorazepam
- Pharmacokinetics
- Miscellaneous Drugs
- DOSAGES
- Selected Antianxiety Drugs
- hydroxyzine
- Pharmacokinetics
- buspirone
- Pharmacokinetics
- DRUGS USED TO TREAT AFFECTIVE DISORDERS
- PREVENTING MEDICATION ERRORS
- Look-Alike Drugs: Bupropion and Buspirone
- ANTIMANIC DRUGS
- Drug Profiles
- ▸ lithium
- Pharmacokinetics
- valproic acid
- Pharmacokinetics
- ANTIDEPRESSANT DRUGS
- DOSAGES
- Selected Antimanic Drugs
- FIGURE 15-1 Biologic amine hypothesis. NE, Norepinephrine.
- FIGURE 15-2 Permissive hypothesis. NE, Norepinephrine; 5-HT, serotonin.
- SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND SECOND- AND THIRD-GENERATION ANTIDEPRESSANTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Box 15-2 Common Symptoms of Serotonin Syndrome
- Table 15-4 Newer Generation Antidepressants: Adverse Effects
- Table 15-5 Newer Generation Antidepressants: Drug Interactions
- DOSAGES
- Selected NGAs
- Drug Profiles
- trazodone
- Pharmacokinetics
- ▸ bupropion
- Pharmacokinetics
- ▸ fluoxetine
- Pharmacokinetics
- venlafaxine
- Pharmacokinetics
- ▸ mirtazapine
- Pharmacokinetics
- TRICYCLIC ANTIDEPRESSANTS
- Mechanism of Action and Drug Effects
- Table 15-6 Tricyclic Antidepressants: Therapeutic and Undesirable Drug Effects by Receptor Site
- Indications
- Contraindications
- Adverse Effects
- Table 15-7 Tricyclic Antidepressants: Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- DOSAGES
- Selected Tricyclic Antidepressants
- Box 15-3 Cyclic Antidepressant Categories
- Tertiary Amine TCAs
- Secondary Amine TCAs
- Tetracyclic Antidepressants
- Drug Profiles
- ▸ amitriptyline
- Pharmacokinetics
- MONOAMINE OXIDASE INHIBITORS
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- St. John’s Wort (Hypericum perforatum)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- Table 15-8 MAOIs: Adverse Effects
- Toxicity and Management of Overdose
- Table 15-9 Food and Drink to Avoid When Taking MAOIs
- DOSAGES
- Selected MAOIs
- Interactions
- Dosages
- ANTIPSYCHOTIC DRUGS
- Mechanism of Action and Drug Effects
- Table 15-10 Major Dopamine Systems in the Brain
- Indications
- Contraindications
- Adverse Effects
- Table 15-11 Antipsychotics: Receptor-Related Adverse Effects
- Table 15-12 Antipsychotics: Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Phenothiazines
- fluphenazine
- DOSAGES
- Selected First-Generation Antipsychotic Drugs
- Table 15-13 Compatibility of Selected Liquid Antipsychotic Dosage Forms with Beverages for Dosing Purposes*
- Pharmacokinetics
- Butyrophenones
- haloperidol
- Pharmacokinetics
- Atypical Antipsychotics
- DOSAGES
- Selected Atypical Antipsychotic Drugs
- clozapine
- Pharmacokinetics
- ▸ risperidone
- Pharmacokinetics
- ▸ olanzapine
- Pharmacokinetics
- quetiapine
- Pharmacokinetics
- ziprasidone
- Pharmacokinetics
- Antipsychotic Drugs Summary
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Antianxiety Drugs
- Lifespan Considerations: The Pediatric Patient
- Psychotherapeutic Drugs
- Lifespan Considerations: The Elderly Patient
- Psychotherapeutic Drugs
- Antimanic Drugs
- Antidepressants
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Ginseng
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- Antipsychotics
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Antianxiety Drugs
- Antimanic Drugs
- Antidepressants
- Antipsychotics
- ♦ EVALUATION
- Patient Teaching Tips
- Antianxiety Drugs
- Antimanic Drugs
- Antidepressant Drugs
- MAOIs and TCAs
- Haloperidol
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 16 Central Nervous System Stimulants and Related Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- CENTRAL NERVOUS SYSTEM STIMULANTS
- Table 16-1 Structurally Related CNS Stimulants
- Table 16-2 CNS Stimulants: Site of Action
- Table 16-3 CNS Stimulants and Related Drugs: Therapeutic Categories
- OVERVIEW OF PATHOPHYSIOLOGY
- ATTENTION DEFICIT HYPERACTIVITY DISORDER
- NARCOLEPSY
- DRUGS FOR ATTENTION DEFICIT HYPERACTIVITY DISORDER AND NARCOLEPSY
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Drug Profiles
- Amphetamines and Related Stimulants
- ▸ amphetamines
- Table 16-4 CNS Stimulants: Common Drug Interactions
- Pharmacokinetics (dextroamphetamine)
- ▸ methylphenidate
- Pharmacokinetics (Immediate Release)
- atomoxetine
- Pharmacokinetics
- modafinil
- Pharmacokinetics
- Miscellaneous Narcolepsy Drugs
- sodium oxybate
- Pharmacokinetics
- OBESITY
- DOSAGES
- Selected CNS Stimulants and Related Drugs
- LEGAL AND ETHICAL PRINCIPLES
- Handling of Prescription Drugs
- ANOREXIANTS
- Mechanism of Action and Drug Effects
- EVIDENCE-BASED PRACTICE
- An Applied Evidence-Based Review of the Diagnosis and Treatment of Obesity in Adults
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Drug Profiles
- Anorexiants
- ▸ phentermine
- ▸ sibutramine
- Pharmacokinetics
- orlistat
- Pharmacokinetics
- MIGRAINE
- ANTIMIGRAINE DRUGS (SEROTONIN AGONISTS)
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Drug Profiles
- Serotonin Agonists
- ▸ sumatriptan
- Pharmacokinetics
- ANALEPTIC-RESPONSIVE RESPIRATORY DEPRESSION SYNDROMES
- ANALEPTICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Drug Profiles
- ▸ caffeine
- Pharmacokinetics
- doxapram
- Table 16-5 Caffeine-Containing Beverages and Drugs
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Selected Herbal Compounds Used for Nervous System Stimulation*
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- CNS Stimulants in General
- Anorexiants
- Drugs Used to Treat ADHD
- Antimigraine Drugs
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 3 Drugs Affecting the Autonomic Nervous System
- Drugs Affecting the Autonomic Nervous System
- STUDY SKILLS TIPS
- PURR APPLICATION
- Planning for the Part
- Part Title
- Part Chapters
- Chapters 19 and 20
- Active Questioning
- Study Groups
- CHAPTER 17 Adrenergic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- SYMPATHETIC NERVOUS SYSTEM
- FIGURE 17-1 The sympathetic nervous system in relation to the entire nervous system. ACh, Acetylcholine; NE, norepinephrine.
- Table 17-1 Adrenergic Receptor Responses to Stimulation
- FIGURE 17-2 The mechanism by which stimulation of a nerve fiber results in a physiologic process; adrenergic drugs mimic this same process. COMT, Catechol ortho-methyltransferase; MAO, monoamine oxidase; NE, norepinephrine.
- ADRENERGIC DRUGS
- FIGURE 17-3 Mechanism of physiologic response to direct-acting sympathomimetics. D, Drug; NE, norepinephrine.
- Table 17-2 Catecholamines and Their Dose-Response Relationship
- FIGURE 17-4 Mechanism of physiologic response to indirect-acting sympathomimetics. D, Drug; NE, norepinephrine.
- FIGURE 17-5 Mechanism of physiologic response to mixed-acting sympathomimetics. D, Drug; NE, norepinephrine.
- Mechanism of Action and Drug Effects
- Indications
- Respiratory Indications
- Indications for Topical Nasal Decongestants
- Ophthalmic Indications
- Cardiovascular Indications
- Epinephrine for Cardiac Arrest
- Contraindications
- Adverse Effects
- Life Span Considerations: The Elderly Patient
- Use of β-Adrenergic Agonists
- Toxicity and Management of Overdose
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- Bronchodilators
- DOSAGES
- Selected Bronchodilators
- ▸ albuterol sulfate
- Pharmacokinetics
- ▸ epinephrine
- Pharmacokinetics
- ▸ salmeterol
- Pharmacokinetics
- Nasal Decongestants
- ▸ pseudoephedrine
- Pharmacokinetics
- Ophthalmic Decongestants
- tetrahydrozoline
- DOSAGES
- Selected Nasal and Ophthalmic Decongestant Adrenergics
- Pharmacokinetics
- Vasoactive Adrenergics
- ▸ dobutamine
- Pharmacokinetics
- ▸ dopamine
- Pharmacokinetics
- DOSAGES
- Selected Vasoactive Adrenergics
- ▸ epinephrine
- Pharmacokinetics
- fenoldopam
- Pharmacokinetics
- midodrine
- Pharmacokinetics
- ▸ norepinephrine
- Pharmacokinetics
- phenylephrine
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- LEGAL AND ETHICAL PRINCIPLES
- Infiltrating Intravenous (IV) Infusions
- Situation
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 18 Adrenergic-Blocking Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- α-BLOCKERS
- Mechanism of Action and Drug Effects
- Indications
- FIGURE 18-1 Mechanisms for αadrenergic competitive and noncompetitive blockade by α-blockers. A, α-blocker; NE, norepinephrine.
- CASE STUDY
- Alternative Therapies for Migraine Headaches
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Table 18-1 α-Blockers: Adverse Effects
- Table 18-2 α-Blockers: Common Drug Interactions
- Interactions
- Dosages
- Drug Profiles
- ergotamine tartrate
- Pharmacokinetics
- phenoxybenzamine hydrochloride
- Pharmacokinetics
- ▸ phentolamine
- Pharmacokinetics
- DOSAGES
- Selected α-Adrenergic-Blocking Drugs
- ▸ prazosin
- Pharmacokinetics
- tolazoline
- Pharmacokinetics
- β-BLOCKERS
- Mechanism of Action and Drug Effects
- Box 18-1 Currently Available β-blockers
- Nonselective β-blockers
- Cardioselective β-blockers
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Table 18-3 β-Blockers: Common Adverse Effects
- Table 18-4 β-Blockers: Drug Interactions
- Dosages
- Drug Profiles
- acebutolol
- Pharmacokinetics
- ▸ atenolol
- Pharmacokinetics
- carvedilol
- DOSAGES
- Selected β-Adrenergic-Blocking Drugs
- Pharmacokinetics
- ▸ esmolol
- Pharmacokinetics
- labetalol
- Pharmacokinetics
- ▸ metoprolol
- Pharmacokinetics
- propranolol
- Pharmacokinetics
- sotalol
- Pharmacokinetics
- PREVENTING MEDICATION ERRORS
- Look-Alike Drugs: Toprol-XL, Topamax, and Tegretol
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- EVIDENCE-BASED PRACTICE
- β-blockers
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 19 Cholinergic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- PARASYMPATHETIC NERVOUS SYSTEM
- FIGURE 19-1 The parasympathetic and sympathetic nervous systems and their relationship to one another. ACh, Acetylcholine; NE, norepinephrine.
- FIGURE 19-2 The sympathetic, parasympathetic, and somatic nervous systems. Note the location of the nicotinic and muscarinic receptors in the parasympathetic nervous system.
- CHOLINERGIC DRUGS
- Mechanism of Action and Drug Effects
- Box 19-1 Cholinergic Drugs
- Direct-Acting Drugs
- Indirect-Acting Drugs
- Indications
- Table 19-1 Cholinergic Agonists: Drug Effects
- Contraindications
- Adverse Effects
- Table 19-2 Cholinergic Drugs: Adverse Effects
- Interactions
- Toxicity and Management of Overdose
- Dosages
- Drug Profiles
- ▸ bethanechol
- EVIDENCE-BASED PRACTICE
- Alzheimer’s Disease and Razadyne ER
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Pharmacokinetics
- cevimeline
- Pharmacokinetics
- ▸ physostigmine
- Pharmacokinetics
- ▸ pyridostigmine
- DOSAGES
- Selected Cholinergic Agonist Drugs
- Pharmacokinetics
- Cholinergic Agonists Used Specifically for Alzheimer’s Disease
- ▸ donepezil
- Pharmacokinetics
- galantamine
- Pharmacokinetics
- rivastigmine
- Pharmacokinetics
- Miscellaneous Alzheimer’s Disease Medications
- memantine
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Ginkgo (Ginkgo biloba)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 20 Cholinergic-Blocking Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- CHOLINERGIC-BLOCKING DRUGS
- Mechanism of Action and Drug Effects
- FIGURE 20-1 Site of action of cholinergic blockers in the parasympathetic nervous system. ACh, Acetylcholine.
- Box 20-1 Cholinergic Blockers Grouped According to Chemical Class
- Natural Drugs
- Synthetic and Semisynthetic Drugs
- Indications
- Table 20-1 Cholinergic Blockers: Drug Effects
- Contraindications
- Adverse Effects
- Interactions
- Table 20-2 Cholinergic Blockers: Adverse Effects
- Toxicity and Management of Overdose
- Dosages
- Drug Profiles
- DOSAGES
- Selected Cholinergic Antagonist (Anticholinergic) Drugs
- ▸ atropine
- Atropine for Sinus Bradycardia
- Pharmacokinetics
- ▸ benztropine mesylate
- ▸ dicyclomine
- Pharmacokinetics
- glycopyrrolate
- Pharmacokinetics
- scopolamine
- Pharmacokinetics
- ▸ tolterodine
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Life Span Considerations: The Elderly Patient
- Overactive Bladder
- EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 4 Drugs Affecting the Cardiovascular and Renal Systems
- Drugs Affecting the Cardiovascular and Renal Systems
- STUDY SKILLS TIPS
- LINKING LEARNING
- Chapter Structure
- Chapter Objectives
- Example Based on Chapter 21 Objectives
- Chapter Headings
- Glossary
- Glossary and Text Relationship
- TEXT NOTATION
- Text Notation Application
- Chapter 26, Paragraphs One and Two
- Discussion
- Chapter 26, Paragraph Three
- Discussion
- CHAPTER 21 Positive Inotropic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- HEART FAILURE AND CARDIAC DYSRHYTHMIAS
- Box 21-1 Myocardial Deficiency and Increased Workload: Common Causes
- Myocardial Deficiency
- Inadequate Contractility
- Inadequate Filling
- Increased Workload
- Pressure Overload
- Volume Overload
- FIGURE 21-1 Conduction system of the heart. AV, Atrioventricular; LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle; SA, sinoatrial. (Modified from Kinney M et al: Comprehensive cardiac care, ed 8, St Louis, 1996, Mosby; Lewis SM, Heitkemper MM, Dirksen SR: Medical-surgical nursing: assessment and management of clinical problems, ed 6, St Louis, 2004, Mosby.)
- CARDIAC GLYCOSIDES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Table 21-1 Cardiac Glycosides: Common Adverse Effects
- Table 21-2 Digoxin Toxicity: Step-by-Step Management
- Life Span Considerations: The Pediatric Patient
- Heart Failure and Cardiac Glycosides
- Interactions
- PREVENTING MEDICATION ERRORS
- The Importance of Decimal Points
- Dosages
- Drug Profiles
- ▸ digoxin
- Pharmacokinetics
- Table 21-3 Cardiac Glycosides: Drug Interactions
- DOSAGES
- Selected Cholinergic Antagonist (Anticholinergic) Drugs
- digoxin immune Fab
- Pharmacokinetics
- PHOSPHODIESTERASE INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- milrinone
- Pharmacokinetics
- MISCELLANEOUS HEART FAILURE DRUGS
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Table 21-4 Conditions Predisposing to Digitalis Toxicity
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 22 Antidysrhythmic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- DYSRHYTHMIAS AND NORMAL CARDIAC ELECTROPHYSIOLOGY
- Normal Electrophysiology
- FIGURE 22-1 Resting membrane potential of a cardiac cell. ATPase, Adenosine triphosphatase.
- FIGURE 22-2 Action potentials. RMP, Resting membrane potential; SA, sinoatrial; TP, threshold potential.
- FIGURE 22-3 Purkinje fiber action potential.
- FIGURE 22-4 Aspects of an action potential. APD, Action potential duration; ERP, effective refractory period; RRP, relative refractory period.
- Table 22-1 Comparison of Action Potentials in Different Cardiac Tissue
- Electrocardiography
- FIGURE 22-5 The waves and intervals of a normal electrocardiogram. (From Goldberger AL: Clinical electrocardiography: a simplified approach, ed 6, St Louis, 1999, Mosby.)
- Common Dysrhythmias
- Table 22-2 Common Dysrhythmias
- Table 22-3 Vaughan Williams Classification of Antidysrhythmic Drugs
- ANTIDYSRHYTHMIC DRUGS
- Mechanism of Action and Drug Effects
- Table 22-4 Antidysrhythmic Drugs: Mechanisms of Action
- Box 22-1 Effects of Antidysrhythmic Drugs
- Class I (moricizine)
- Class Ia (disopyramide, procainamide, quinidine)
- Class Ib (lidocaine, mexiletine, phenytoin)
- Class Ic (flecainide, propafenone)
- Class II (β-blockers [e.g., atenolol, esmolol, metoprolol])
- Class III (amiodarone, sotalol*, ibutilide, dofetilide)
- Class IV (diltiazem, verapamil)
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Table 22-5 Antidysrhythmic Drugs: Indication
- Drug Profiles
- Class Ia Drugs
- Table 22-6 Common Adverse Effects of Various Antidysrhythmic Drugs
- procainamide
- Table 22-7 Common Electrocardiographic Effects of Various Antidysrhythmic Drugs
- Table 22-8 Selected Antidysrhythmic Drugs: Management of Overdose
- Pharmacokinetics
- quinidine
- Table 22-9 Common Drug Interactions for Selected Antidysrhythmic Drugs
- Pharmacokinetics
- Class Ib Drugs
- ▸ lidocaine
- DOSAGES
- Selected Antiepileptic Drugs
- Pharmacokinetics
- mexiletine
- Pharmacokinetics
- Class Ic Drugs
- flecainide
- Pharmacokinetics
- propafenone
- Pharmacokinetics
- Class II Drugs
- ▸ atenolol
- Pharmacokinetics
- esmolol
- Pharmacokinetics
- ▸ metoprolol
- Pharmacokinetics
- ▸ propranolol
- Pharmacokinetics
- ▸ sotalol
- Pharmacokinetics
- Class III Drugs
- Amiodarone for Ventricular Tachycardia
- Amiodarone for Ventricular Fibrillation
- ▸ amiodarone
- Table 22-10 Recommendations for Oral Dosage after IV Infusion of Amiodarone
- Pharmacokinetics
- ibutilide
- Pharmacokinetics
- Class IV Drugs
- ▸ diltiazem
- Cardiac Effects of Diltiazem Injection
- Pharmacokinetics
- ▸ verapamil
- Pharmacokinetics
- Unclassified Antidysrhythmics
- adenosine
- Cardiac Effects of Adenosine
- Pharmacokinetics
- PHARMACOKINETIC BRIDGE to Nursing Practice
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- EVIDENCE-BASED PRACTICE
- Antidysrhythmics and the Elderly Patient
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 23 Antianginal Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ANGINA AND CORONARY ARTERY DISEASE
- Acute Myocardial Infarction
- Table 23-1 Antianginal Drugs: Therapeutic Effects
- ANTIANGINAL DRUGS
- FIGURE 23-1 Benefit of drug therapy for angina through increasing oxygen supply and decreasing oxygen demands.
- NITRATES AND NITRITES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ isosorbide dinitrate
- Pharmacokinetics
- ▸ isosorbide mononitrate
- Pharmacokinetics
- ▸ nitroglycerin
- DOSAGES
- Selected Antianginal Nitrate Coronary Vasodilators
- PREVENTING MEDICATION ERRORS
- Rate vs. Dose
- Pharmacokinetics
- β-BLOCKERS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 23-2 β-Blockers: Adverse Effects
- Table 23-3 β-Blockers: Common Drug Interactions
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- DOSAGES
- Selected β-Adrenergic-Blocking Drugs
- ▸ atenolol
- Pharmacokinetics
- ▸ metoprolol
- Pharmacokinetics
- CALCIUM CHANNEL BLOCKERS
- Table 23-4 Classification of Calcium Channel Blockers
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Table 23-5 Calcium Channel Blockers: Adverse Effects
- Table 23-6 Calcium Channel Blockers: Common Drug Interactions
- Drug Profiles
- ▸ diltiazem
- Pharmacokinetics
- amlodipine
- Pharmacokinetics
- MISCELLANEOUS ANTIANGINAL DRUGS
- Drug Profiles
- ranolazine
- DOSAGES
- Selected Calcium Channel-Blocking Drugs
- SUMMARY OF ANTIANGINAL PHARMACOLOGY
- PHARMACOKINETIC BRIDGE To Nursing Practice
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Nitroglycerin
- Isosorbide Dinitrate or Isosorbide Mononitrate
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 24 Antihypertensive Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- Box 24-1 New Hypertension Guidelines—The Seventh Report
- HYPERTENSION
- Evidence-Based Practice
- Effects of Exercise on Blood Pressure in Those 55 Years of Age and Older
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Table 24-1 Classification and Management of Blood Pressure
- FIGURE 24-1 Normal regulation of blood pressure and corresponding medications. ACE, Angiotensin-converting enzyme; CNS, central nervous system.
- ANTIHYPERTENSIVE DRUGS
- Box 24-2 Categories and Subcategories of Antihypertensive Drugs
- Adrenergic Drugs
- Angiotensin-Converting Enzyme Inhibitors
- Angiotensin II Receptor Blockers
- Calcium Channel Blockers
- Diuretics
- Vasodilators
- FIGURE 24-2 Location of the nicotinic receptors in the parasympathetic and sympathetic nervous systems. ACh, Acetylcholine; NE, norepinephrine.
- REVIEW OF AUTONOMIC NEUROTRANSMISSION
- CULTURAL IMPLICATIONS
- Antihypertensive Drug Therapy
- ADRENERGIC DRUGS
- Mechanism of Action and Drug Effects
- Renin-Angiotensin in Control of Blood Pressure
- FIGURE 24-3 Site and mechanism of action of the various antihypertensive drugs. (From U.S. Department of Health and Human Services: The seventh report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7), Washington, DC, 2003, National Institutes of Health. In Lewis SM, Heitkemper MM, Dirksen SR: Medical-surgical nursing: assessment and management of clinical problems, ed 6, St Louis, 2003, Mosby.)
- Indications
- Contraindications
- Adverse Effects
- Table 24-2 Adrenergic Drugs: Drug Interactions
- Interactions
- Dosages
- Drug Profiles
- α2-Adrenergic Receptor Stimulators (Agonists)
- ▸ clonidine
- DOSAGES
- Selected Antihypertensive Drugs: Adrenergic Agonist and Antagonists
- Pharmacokinetics
- α1-Blockers
- prazosin
- Pharmacokinetics
- Dual-Action α1 and β Receptor Blockers
- carvedilol
- Pharmacokinetics
- ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
- Table 24-3 ACE Inhibitors: Distinguishing Characteristics
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 24-4 ACE Inhibitors: Therapeutic Effects
- DOSAGES
- Selected Antihypertensive Drugs: ACE Inhibitors and Angiotensin II Receptor Blockers
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- ▸ captopril
- Pharmacokinetics
- enalapril
- Pharmacokinetics
- ANGIOTENSIN II RECEPTOR BLOCKERS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Table 24-5 Angiotensin II Receptor Blockers (ARBs): Drug Interactions
- Dosages
- Drug Profile
- ▸ losartan
- Pharmacokinetics
- CALCIUM CHANNEL BLOCKERS
- DIURETICS
- VASODILATORS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Table 24-6 Direct-Acting Vasodilators: Drug Interactions
- Drug Profiles
- ▸ hydralazine hydrochloride
- Pharmacokinetics
- DOSAGES
- Selected Antihypertensive Drugs: Vasodilators
- sodium nitroprusside
- Pharmacokinetics
- MISCELLANEOUS ANTIHYPERTENSIVE DRUGS
- Drug Profiles
- eplerenone
- bosentan
- treprostinil
- DOSAGES
- Miscellaneous Antihypertensive Drugs
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Sodium Nitroprusside
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- CASE STUDY
- Hypertension
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Antihypertensives in General
- α-Adrenergic Agonists
- β-Blockers
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 25 Diuretic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- OVERVIEW OF RENAL PHYSIOLOGY
- DIURETIC DRUGS
- FIGURE 25-1 The nephron and diuretic sites of action. ADH, Antidiuretic hormone.
- Table 25-1 Classification of Diuretics
- CARBONIC ANHYDRASE INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- acetazolamide
- Pharmacokinetics
- LOOP DIURETICS
- Mechanism of Action and Drug Effects
- Summary of Major Drug Effects of Loop Diuretics
- Indications
- Contraindications
- Table 25-2 Loop Diuretics: Common Adverse Effects
- Table 25-3 Loop Diuretics: Common Drug Interactions
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- Pharmacokinetics
- ▸ furosemide
- DOSAGES
- Selected Loop Diuretics and Osmotic Diuretics
- Pharmacokinetics
- OSMOTIC DIURETICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ mannitol
- Pharmacokinetics
- POTASSIUM-SPARING DIURETICS
- Mechanism of Action and Drug Effects
- Life Span Considerations: The Pediatric Patient
- Diuretics
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 25-4 Potassium-Sparing Diuretics: Common Adverse Effects
- Dosages
- Drug Profiles
- amiloride
- Pharmacokinetics
- ▸ spironolactone
- Pharmacokinetics
- triamterene
- Pharmacokinetics
- DOSAGES
- Selected Potassium-Sparing Diuretic Drugs
- THIAZIDES AND THIAZIDE-LIKE DIURETICS
- Mechanism of Action and Drug Effects
- Indications
- Table 25-5 Thiazide and Thiazide-Like Diuretics: Potential Adverse Effects
- Contraindications
- Adverse Effects
- Table 25-6 Thiazide and Thiazide-Like Diuretics: Common Drug Interactions
- DOSAGES
- Thiazide and Selected Thiazide-Like Diuretic Drugs
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- ▸ hydrochlorothiazide
- Pharmacokinetics
- metolazone
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CASE STUDY
- Diuretic Therapy
- Life Span Considerations: The Elderly Patient
- Diuretic Therapy
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 26 Fluids and Electrolytes
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- PHYSIOLOGY OF FLUID BALANCE
- FIGURE 26-1 Distribution of total body water (TBW). ECF, Extracellular fluid; ICF, intracellular fluid; ISF, interstitial fluid; PV, plasma volume.
- Table 26-1 Fluid Location: Descriptive Terms and Actual Volumes
- FIGURE 26-2 Colloid osmotic pressure (oncotic pressure). As shown, the colloids inside the blood vessel are too large to pass through the vessel wall. The resulting oncotic pressure exerted by the colloids draws fluid from the surrounding tissues and other extravascular spaces into the blood vessels and also keeps fluid inside the blood vessel.
- Table 26-2 Types of Dehydration
- Table 26-3 Conditions Leading to Fluid Loss or Dehydration and Associated Corresponding Symptoms*
- CRYSTALLOIDS
- Mechanism of Action and Drug Effects
- Table 26-4 Crystalloids
- Indications
- Contraindications
- Adverse Effects
- Table 26-5 Crystalloids and Colloids: Dosing Guidelines
- Interactions
- Dosages
- Drug Profiles
- sodium chloride
- Pharmacokinetics
- COLLOIDS
- Table 26-6 Commonly Used Colloids
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- albumin
- Pharmacokinetics
- dextran
- Pharmacokinetics
- BLOOD PRODUCTS
- Mechanism of Action and Drug Effects
- Table 26-7 Blood Products
- Table 26-8 Blood Products: Indications
- Indications
- Contraindications
- Adverse Effects
- Table 26-9 Suggested Guidelines for Blood Products: Management of Bleeding
- Interactions
- Dosages
- Drug Profiles
- Packed Red Blood Cells
- Fresh Frozen Plasma
- PHYSIOLOGY OF ELECTROLYTE BALANCE
- POTASSIUM
- Box 26-1 Symptoms of Hypokalemia
- Early
- Late
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- Pharmacokinetics
- Table 26-10 Potassium: Various Salt Forms
- sodium polystyrene sulfonate (potassium exchange resin)
- SODIUM
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- sodium chloride
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Calcium
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 27 Coagulation Modifier Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- FIGURE 27-1 Coagulation pathway and factors: extrinsic pathway. Plt, Platelets.
- COAGULATION AND HEMOSTASIS
- FIGURE 27-2 Coagulation pathway and factors: intrinsic pathway. HMW-K, High-molecular weight kininogen; Plt, platelets.
- COAGULATION-MODIFYING DRUGS
- FIGURE 27-3 The fibrinolytic system.
- Table 27-1 Coagulation Modifiers: Comparison of Drug Subclasses
- ANTICOAGULANTS
- Case Study
- Heparin Therapy
- Mechanism of Action and Drug Effects
- Heparin for Acute Coronary Syndrome
- Indications
- Heparin for Atrial Fibrillation
- Contraindications
- Adverse Effects
- Interactions
- Table 27-2 Anticoagulants: Common Adverse Effects
- Toxicity and Management of Overdose
- Table 27-3 Anticoagulants: Drug Interactions
- Dosages
- Drug Profiles
- ▸ warfarin
- Pharmacokinetics
- ▸ enoxaparin
- DOSAGES
- Selected Anticoagulant Drugs
- Pharmacokinetics
- ▸ heparin
- Pharmacokinetics
- lepirudin
- Pharmacokinetics
- argatroban
- Pharmacokinetics
- PLATELET PHYSIOLOGY
- FIGURE 27-4 Relationship between platelets and clotting cascade. ADP, Adenosine diphosphate; 5-HT, serotonin; PF4, platelet factor 4; TXA2, thromboxane A2.
- ANTIPLATELET DRUGS
- Mechanism of Action and Drug Effects
- FIGURE 27-5 Cyclooxygenase pathway. PG, Prostaglandin; TXA2, thromboxane A2.
- Indications
- Contraindications
- Adverse Effects
- Table 27-4 Selected Antiplatelet Drugs: Adverse Effects
- Interactions
- Drug Profiles
- Dosages
- ▸ aspirin
- DOSAGES
- Selected Antiplatelet Drugs
- Pharmacokinetics
- ▸ clopidogrel
- Pharmacokinetics
- ▸ eptifibatide
- Pharmacokinetics
- ANTIFIBRINOLYTIC DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 27-5 Antifibrinolytics: Mechanisms of Action
- Interactions
- Dosages
- Drug Profiles
- aminocaproic acid
- Pharmacokinetics
- desmopressin
- Table 27-6 Antifibrinolytics: Adverse Effects
- DOSAGES
- Selected Antifibrinolytic Drugs
- Pharmacokinetics
- THROMBOLYTIC DRUGS
- Thrombolytic Drugs
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- ▸ alteplase
- Pharmacokinetics
- ▸ streptokinase
- DOSAGES
- Selected Thrombolytic Drugs
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Anticoagulants
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Box 27-1 Anticoagulation Therapy and Related Nursing Considerations
- Subcutaneous Heparin Injections
- Intravenous Heparin Administration
- Oral Anticoagulant Administration
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 28 Antilipemic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Garlic (allium sativum)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Flax
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- LIPIDS AND LIPID ABNORMALITIES
- PRIMARY FORMS OF LIPIDS
- Table 28-1 Lipoprotein Classification
- CHOLESTEROL HOMEOSTASIS
- FIGURE 28-1 Cholesterol homeostasis. CE, Cholesterol ester; HDL, high-density lipoprotein; HMG-CoA, hydroxymethylglutaryl-coenzyme A; IDL, intermediate-density lipoprotein; LCAT, lecithin cholesterol acetyltransferase; LDL, low-density lipoprotein; TG, triglyceride; VLDL, very-low-density lipoprotein.
- ATHEROSCLEROTIC PLAQUE FORMATION
- LINK BETWEEN CHOLESTEROL AND CORONARY HEART DISEASE
- Evidence-Based Practice
- Statins and Stroke Reduction in Patients With and Without Coronary Heart Disease
- Review
- Type of Evidence and Type of Research
- Results of Study
- Link of Evidence to Nursing Practice
- HYPERLIPIDEMIAS AND TREATMENT GUIDELINES
- Box 28-1 Coronary Heart Disease: Risk Factors
- Positive Risk Factors
- Negative Risk Factors
- Table 28-2 Types of Hyperlipidemias
- Table 28-3 Treatment Decisions Based on LDL Cholesterol Level
- Box 28-2 Identifying Features of the Metabolic Syndrome
- HMG–CoA Reductase Inhibitors
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 28-4 HMG—CoA Reductase Inhibitors: Potential Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Laboratory Test Interactions
- Dosages
- Drug Profiles
- ▸ atorvastatin
- Pharmacokinetics
- OTHER ANTILIPEMIC DRUGS
- BILE ACID SEQUESTRANTS
- Mechanism of Action and Drug Effects
- Table 28-5 Bile Acid Sequestrants: Adverse Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- ▸ cholestyramine
- NIACIN
- Mechanism of Action and Drug Effects
- Indications
- DOSAGES
- Selected Antilipemic Drugs
- Table 28-6 Nicotinic Acid: Potential Adverse Effects
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ niacin
- Pharmacokinetics
- FIBRIC ACID DERIVATIVES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 28-7 Fibric Acid Derivatives: Potential Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- Fibric Acid Derivatives (Fibrates)
- gemfibrozil
- Pharmacokinetics
- Cholesterol Absorption Inhibitors
- ezetimibe
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Coronary Heart Disease
- ♦ EVALUATION
- Patient Teaching Tips
- Points To Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 5 Drugs Affecting the Endocrine System
- Drugs Affecting the Endocrine System
- STUDY SKILLS TIPS
- QUESTIONING STRATEGY
- Part Title
- Chapter Titles
- Chapter Objectives
- Chapter Headings
- Type 1 Diabetes Mellitus
- Mechanism of Action and Drug Effects
- Print Conventions Within the Body of the Chapter
- Chapter Tables
- CHAPTER 29 Pituitary Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ENDOCRINE SYSTEM
- Box 29-1 Hormones of the Anterior and Posterior Pituitary
- Anterior Pituitary Adenohypophysis
- Posterior Pituitary (Neurohypophysis)
- FIGURE 29-1 Pituitary hormones. (From McKenry LM, Tessier E, Hogan MA: Mosby’s pharmacology in nursing,ed 22, St Louis, 2006, Mosby.)
- PITUITARY DRUGS
- Mechanism of Action and Drug Effects
- Table 29-1 Anterior and Posterior Pituitary Hormones and Drugs
- Indications
- Table 29-2 Corticotropin: Common Adverse Effects
- Table 29-3 Desmopressin and Vasopressin: Common Adverse Effects
- Table 29-4 Growth Hormone Analogs: Common Adverse Effects
- Table 29-5 Selected Drug Interactions Involving Pituitary Drugs
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ corticotropin
- Pharmacokinetics
- DOSAGES
- Selected Pituitary Drugs
- Selected Pituitary Drugs
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Box 29-2 Pituitary Drugs: Assessment Data
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 30 Thyroid and Antithyroid Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- THYROID FUNCTION
- HYPOTHYROIDISM
- THYROID AUGMENTATION DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 30-1 Thyroid Drugs: Clinically Equivalent Doses
- Interactions
- Dosages
- Table 30-2 Thyroid Drugs: Common Adverse Effects
- Drug Profiles
- ▸ levothyroxine
- Pharmacokinetics
- DOSAGES
- Selected Thyroid Drugs
- HYPERTHYROIDISM
- ANTITHYROID DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Table 30-3 Antithyroid Drugs: Common Adverse Effects
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ propylthiouracil
- DOSAGES
- Selected Antithyroid Drugs
- Pharmacokinetics
- PHARMACOKINETIC BRIDGE TO NURSING PRACTICE
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Life Span Considerations: The Elderly Patient
- Thyroid Hormones
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 31 Antidiabetic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- PANCREAS
- DIABETES MELLITUS
- Box 31-1 Criteria for Diagnosis of Diabetes
- Box 31-2 Major Long-Term Consequences of Diabetes (Type 1 and Type 2)
- Table 31-1 Type 1 and Type 2 Diabetes: Characteristics
- Type 1 Diabetes Mellitus
- Acute Diabetic Complications: Diabetic Ketoacidosis and Hyperosmolar Nonketotic Syndrome
- Type 2 Diabetes Mellitus
- FIGURE 31-1 Islet of Langerhans. (From Boron WF, Boulapaep EL:Medical physiology, Philadelphia, 2003, Saunders.)
- Table 31-2 Comparison of Some Salient Features of Diabetic Ketoacidosis and Hyperosmolar Nonketotic Syndrome
- Gestational Diabetes
- Prevention and Screening
- Nonpharmacologic Treatment Interventions
- ANTIDIABETIC DRUGS
- INSULINS
- Table 31-3 Human Insulins and Analogues: Comparison of Pharmacokinetic Properties
- Table 31-4 Insulin Mixing Compatibilities
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Box 31-3 Intensive Insulin Therapy and Tight Glucose Control
- Table 31-5 Insulin: Common Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Insulins
- DOSAGES
- Human-Based Insulin Products
- Rapid-Acting Insulins
- ▸ insulin lispro and insulin aspart
- Table 31-6 Sources of Available Insulin Products
- Table 31-7 Considerations for the Use of Antidiabetic Drugs and Insulin
- Short-Acting Insulin
- ▸ regular insulin
- Intermediate-Acting Insulins
- ▸ insulin zinc suspension (Lente) and insulin isophane suspension (NPH)
- Long-Acting Insulins
- ▸ extended insulin zinc suspension (Ultralente) and glargine
- Fixed-Combination Insulins
- Sliding-Scale Insulin Dosing
- ORAL ANTIDIABETIC DRUGS
- Mechanism of Action and Drug Effects
- Sulfonylureas
- Meglitinides
- Biguanide
- Table 31-8 Sulfonylurea Drugs: Qualitative Comparison of Pharmacokinetic Properties
- Thiazolidinediones
- α-Glucosidase Inhibitors
- Indications
- Contraindications
- Adverse Effects
- Sulfonylureas
- Meglitinides
- Biguanide
- Thiazolidinediones
- α-Glucosidase Inhibitors
- Interactions
- Sulfonylureas
- Meglitinides
- Biguanide
- Thiazolidinediones
- α-Glucosidase Inhibitors
- Dosages
- Drug Profiles
- acarbose
- DOSAGES
- Selected Oral Antidiabetic Drugs
- Pharmacokinetics
- ▸ glipizide
- Pharmacokinetics
- ▸ glyburide
- Pharmacokinetics
- glimepiride
- Pharmacokinetics
- ▸ metformin
- Pharmacokinetics
- repaglinide
- Pharmacokinetics
- ▸ rosiglitazone
- Pharmacokinetics
- MISCELLANEOUS ANTIDIABETIC DRUGS
- Amylin Mimetic
- Incretin Mimetic
- HYPOGLYCEMIA
- GLUCOSE-ELEVATING DRUGS
- PHARMACOKINETIC BRIDGE to Nursing Practice
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- CASE STUDY
- Diabetes Mellitus
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Box 31-4 Administration, Handling, and Storage of Insulin
- Dosages, Storage, Handling, and Mixing
- Administration
- ♦ EVALUATION
- EVIDENCE-BASED PRACTICE
- Tight Insulin Control
- Review
- Type of Evidence
- Results of Study
- Link of Evidence to Nursing Practice
- Patient Teaching Tips
- Insulin Therapy
- Table 31-9 Diabetes Care: Correlation of Glycosylated Hemoglobin Levels with Mean Serum Glucose Levels
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 32 Adrenal Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ADRENAL SYSTEM
- Table 32-1 Adrenal Gland: Characteristics
- Box 32-1 Adrenal Cortex Hormones: Biologic Functions
- Glucocorticoids
- Mineralocorticoids
- ADRENAL DRUGS
- Mechanism of Action and Drug Effects
- Table 32-2 Available Synthetic Corticosteroids
- Indications
- Table 32-3 Systemic Glucocorticoids: A Comparison
- Contraindications
- Adverse Effects
- Interactions
- Table 32-4 Corticosteroids: Common Adverse Effects
- Dosages
- Drug Profiles
- Corticosteroids
- DOSAGES
- Selected Antiadrenal and Corticosteroid Drugs
- ▸ fludrocortisone
- Pharmacokinetics
- ▸ prednisone
- Pharmacokinetics
- Antiadrenals
- ▸ aminoglutethimide
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 33 Women’s Health Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- OVERVIEW OF FEMALE REPRODUCTIVE FUNCTIONS
- Table 33-1 Phases of the Menstrual Cycle
- FIGURE 33-1 Hormonal activity during the monthly menstrual cycle. Gonadotropin-releasing hormone (Gn-RH) from the hypothalamus stimulates the pituitary gland, causing it to secrete follicle-stimulating hormone (FSH) early in the cycle (coinciding with the menses) and later luteinizing hormone (LH). FSH stimulates the ovaries to produce estrogen (primarily estradiol). Later in the cycle the combined surges in the levels of estrogen, Gn-RH, FSH, and LH stimulate ovulation. The corpus luteum then secretes estrogen and progesterone, providing negative feedback to the hypothalamus and pituitary gland to reduce Gn-RH, FSH, and LH secretions. If the ovum (egg) is not fertilized by a spermatozoon, levels of estrogen and progesterone then fall to their monthly lows, Gn-RH and FSH rise again, and the onset of menses begins a new cycle.
- FEMALE SEX HORMONES
- ESTROGENS
- FIGURE 33-2 Chemical structures for steroid nucleus. A, Detailed structure. B, Abbreviated structure.
- Mechanism of Action and Drug Effects
- Box 33-1 Diethylstilbestrol
- Indications
- Contraindications
- Box 33-2 Indications for Estrogen Therapy
- Table 33-2 Estrogens: Common Adverse Effects
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ estrogen
- DOSAGES
- Selected Estrogenic Drugs
- CULTURAL IMPLICATIONS
- Racial Disparities in Survival of Women with Endometrial Cancers
- PROGESTINS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 33-3 Progestins: Common Adverse Effects
- Dosages
- Drug Profiles
- ▸ medroxyprogesterone
- Pharmacokinetics
- megestrol
- Pharmacokinetics
- CONTRACEPTIVE DRUGS
- DOSAGES
- Selected Progestational Drugs
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 33-4 Oral Contraceptives: Common Adverse Effects
- Dosages
- Drug Profiles
- Contraceptive Drugs
- DOSAGES
- Selected Contraceptive Drugs
- CURRENT DRUG THERAPY FOR OSTEOPOROSIS
- CASE STUDY
- Osteoporosis
- Mechanism of Action and Drug Effects
- Bisphosphonates
- Selective Estrogen Receptor Modulators
- Calcitonin
- Teriparatide
- Indications
- Contraindications
- Bisphosphonates
- Selective Estrogen Receptor Modulators
- Calcitonin
- Teriparatide
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ alendronate
- Pharmacokinetics
- raloxifene
- DOSAGES
- Selected Drugs Used Specifically for Osteoporosis
- Pharmacokinetics
- calcitonin
- Pharmacokinetics (Nasal Spray)
- DRUG THERAPY RELATED TO PREGNANCY, LABOR, DELIVERY, AND THE POSTPARTUM PERIOD
- FERTILITY DRUGS
- Mechanism Of Action And Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 33-5 Fertility Drugs: Most Common Adverse Effects
- DOSAGES
- Selected Fertility Drugs
- Interactions
- Dosages
- Drug Profiles
- choriogonadotropin alfa
- Pharmacokinetics
- clomiphene
- Pharmacokinetics
- ▸ menotropins
- Pharmacokinetics
- LABOR, DELIVERY, AND POSTPARTUM DRUGS: UTERINE-ACTIVE MEDICATIONS
- Uterine Stimulants
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 33-6 Oxytocic Drugs: Most Common Adverse Effects
- Dosages
- Drug Profiles
- ▸ dinoprostone
- Pharmacokinetics
- ▸ methylergonovine
- Pharmacokinetics
- mifepristone
- Pharmacokinetics
- ▸ oxytocin
- DOSAGES
- Selected Uterine Stimulants
- Pharmacokinetics
- Uterine Relaxants
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Table 33-7 Tocolytic Drugs: Most Common Adverse Effects
- Dosages
- Drug Profiles
- ritodrine
- Pharmacokinetics
- terbutaline
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- DOSAGES
- Selected Uterine Relaxants
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 34 Men’s Health Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- MALE REPRODUCTIVE SYSTEM
- ANDROGENS AND OTHER DRUGS PERTAINING TO MEN’S HEALTH
- Mechanism of Action and Drug Effects
- CULTURAL IMPLICATIONS
- Men’s Health Concerns and Screening
- Indications
- Box 34-1 Currently Available Men’s Health Drugs
- a1-Adrenergic Blockers
- Anabolic Steroids
- Other Androgens
- Antiandrogens
- 5α-Reductase Inhibitors
- Gonadotropin-Releasing Hormone Analogues
- Peripheral Vasodilator
- Drugs for Erectile Dysfunction
- Table 34-1 Men’s Health Drugs: Indications
- Contraindications
- Adverse Effects
- Table 34-2 Mens’ Health Drugs: Selected Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- finasteride
- DOSAGES
- Selected Men’s Health Drugs
- Pharmacokinetics
- ▸ sildenafil
- Pharmacokinetics
- ▸ testosterone
- Pharmacokinetics
- PHARMACOKINETIC BRIDGE to Nursing Practice
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Life Span Considerations: The Elderly Patient
- Sildenafil: Use and Concerns
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Saw Palmetto (Serenoa repens, Sabal serrulata)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 6 Drugs Affecting the Respiratory System
- Drugs Affecting the Respiratory System
- STUDY SKILLS TIPS
- STUDY ON THE RUN, PURR
- Where Is the Time?
- SOTR and Plan
- SOTR and Vocabulary
- Creating Vocabulary Cards with SOTR
- SOTR and Vocabulary Review
- SOTR and Chapter Review
- CHAPTER 35 Antihistamines, Decongestants, Antitussives, and Expectorants
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- COLD MEDICATIONS
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Echinacea (Echinacea)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ANTIHISTAMINES
- Mechanism of Action and Drug Effects
- FIGURE 35-1 Comparison of efficacy and adverse effects of selected antihistamines.
- Indications
- Contraindications
- Table 35-1 Effects of Various Antihistamines
- Table 35-2 Antihistamines: Drug Effects
- Adverse Effects
- Table 35-3 Antihistamines: Reported Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Nonsedating Antihistamines
- ▸ loratadine
- Pharmacokinetics
- Traditional Antihistamines
- ▸ diphenhydramine
- DOSAGES
- Selected Antihistamines
- Pharmacokinetics
- DECONGESTANTS
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Goldenseal (Hydrastis canadensis)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- naphazoline
- DOSAGES
- Selected Decongestant, Expectorant, and Antitussive Drugs
- Pharmacokinetics
- ANTITUSSIVES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- benzonatate
- Pharmacokinetics
- codeine
- Pharmacokinetics
- ▸ dextromethorphan
- Pharmacokinetics
- EXPECTORANTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Table 35-4 Expectorants: Reported Adverse Effects
- Drug Profiles
- ▸ guaifenesin
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- CASE STUDY
- Decongestants
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 36 Bronchodilators and Other Respiratory Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- DISEASES OF THE RESPIRATORY SYSTEM
- ASTHMA
- Box 36-1 Steps Involved in an Attack of Allergic Asthma
- Box 36-2 Classifications of Drugs Used to Treat Asthma
- Long-Term Control
- Quick Relief
- Table 36-1 Stepwise Therapy for the Management of Asthma
- CHRONIC BRONCHITIS
- EMPHYSEMA
- TREATMENT OF DISEASES OF THE LOWER RESPIRATORY TRACT
- BRONCHODILATORS
- β-ADRENERGIC AGONISTS
- Mechanism of Action and Drug Effects
- Table 36-2 Mechanisms of Antiasthmatic Drug Action
- Table 36-3 β-Agonist Bronchodilators
- PREVENTING MEDICATION ERRORS
- Oral Ingestion of Capsules for Inhalation Devices
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ albuterol
- Pharmacokinetics
- ANTICHOLINERGICS
- Mechanism of Action and Drug Effects
- DOSAGES
- Bronchodilators
- Indications
- Contraindications
- Adverse Effects
- Drug Interactions
- Dosages
- Drug Profiles
- ipratropium
- Pharmacokinetics
- XANTHINE DERIVATIVES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ theophylline
- DOSAGES
- Theophylline Salts
- Table 36-4 Available Theophylline Preparations
- Pharmacokinetics
- NONBRONCHODILATING RESPIRATORY DRUGS
- ANTILEUKOTRIENE DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 36-5 Drug Interactions: Antileukotriene Drugs
- Interactions
- Dosages
- Drug Profiles
- ▸ montelukast
- DOSAGES
- Selected Antileukotriene Drugs
- Pharmacokinetics
- CORTICOSTEROIDS
- Mechanism of Action and Drug Effects
- Indications
- Table 36-6 White Blood Cells (Leukocytes)
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- fluticasone
- DOSAGES
- Selected Corticosteroids
- Pharmacokinetics
- CASE STUDY
- Chronic Obstructive Pulmonary Disease
- methylprednisolone
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Life Span Considerations: The Elderly Patient
- Xanthine Derivatives
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- LEGAL AND ETHICAL PRINCIPLES
- Chlorofluorocarbons and the Environment
- ♦ EVALUATION
- Patient Teaching Tips
- β-Agonists
- Xanthines
- Anticholinergics
- Corticosteroids/Glucocorticoids
- Leukotriene Antagonists
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 7 Antiinfective and Antiinflammatory Drugs
- Antiinfective and Antiinflammatory Drugs
- STUDY SKILLS TIPS
- NURSING PROCESS
- ASSESSMENT
- NURSING DIAGNOSES
- EVALUATION
- CHAPTER 37 Antibiotics Part 1
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- MICROBIAL INFECTION
- FIGURE 37-1 General morphology of bacteria. (From Murray PR et al: Medical microbiology, St Louis, 2002, Mosby.)
- FIGURE 37-2 A dividing bacterial cell with a single flagellum, four sex pili, numerous common fibrae, a cell wall, a cytoplasmic membrane, two nuclear bodies, three mesosomes, and numerous ribosomes. (From Greenwood D et al: Medical microbiology, ed 16, Edinburgh, 2002, Elsevier Science.)
- FIGURE 37-3 Gram-stain differentiation of bacteria. The crystal violet of Gram stain is precipitated by Gram iodine and is trapped in the thick peptidoglycan layer in gram-positive bacteria. The decolorizer disperses the gram-negative outer membrane and washes the crystal violet from the thin layer of peptidoglycan. Gram-negative bacteria are visualized by the red counterstain. (From Murray PR et al: Medical microbiology, St Louis, 2002, Mosby.)
- FIGURE 37-4 Gram-positive and gram-negative bacteria. A gram-positive bacterium has a thick layer of peptidoglycan (left). A gram-negative bacterium has a thin peptidoglycan layer and an outer membrane (right). Structures in parentheses are not found in all bacteria. (From Murray PR et al: Medical microbiology, St Louis, 2002, Mosby.)
- FIGURE 37-5 Molecules on the surface of gram-negative and gram-positive bacteria involved in pathogenesis. Not shown is the type 3 secretory apparatus of gram-negative bacteria. (From Cotran RS, Kumar V, Collins T: Robbins pathologic basis of disease, ed 6, Philadelphia, 1999, Saunders.)
- GENERAL PRINCIPLES OF ANTIBIOTIC THERAPY
- ANTIBIOTICS
- FIGURE 37-6 Basic sites of antibiotic activity. DNA, Deoxyribonucleic acid; mRNA, messenger ribonucleic acid; RNA, ribonucleic acid. (From Murray PR et al: Medical microbiology, St Louis, 2002, Mosby.)
- SULFONAMIDES
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 37-1 Sulfonamides: Reported Adverse Effects
- Dosages
- Drug Profiles
- sulfamethoxazole-trimethoprim (co-trimoxazole)
- Pharmacokinetics
- β-LACTAM ANTIBIOTICS
- DOSAGES
- Selected Sulfonamides and Combination Drug Products
- FIGURE 37-7 Chemical structure of penicillins showing the β-lactam ring. R, Variable portion of drug chemical structure.
- PENICILLINS
- Mechanism of Action and Drug Effects
- Table 37-2 Classification of Penicillins
- Indications
- Contraindications
- Adverse Effects
- Table 37-3 Penicillins: Reported Adverse Effects
- Interactions
- Table 37-4 Penicillins: Drug Interactions
- Dosages
- Drug Profiles
- Natural Penicillins
- ▸ penicillin G and penicillin V potassium
- Pharmacokinetics
- Penicillinase-Resistant Penicillins
- nafcillin
- Pharmacokinetics
- Aminopenicillins
- ▸ amoxicillin
- Pharmacokinetics
- ampicillin
- DOSAGES
- Selected Penicillins
- Pharmacokinetics
- Extended-Spectrum Penicillins
- Pharmacokinetics
- Half-Life of Intravenously Administered Ampicillin
- CEPHALOSPORINS
- Table 37-5 Cephalosporins: Parenteral and Oral Preparations
- Table 37-6 Cephalosporins: Drug Interactions
- Dosages
- DOSAGES
- Selected Cephalosporins
- Drug Profiles
- First-Generation Cephalosporins
- ▸ cefazolin
- Pharmacokinetics
- ▸ cephalexin
- Pharmacokinetics
- Second-Generation Cephalosporins
- ▸ cefoxitin
- Pharmacokinetics
- cefuroxime
- Pharmacokinetics
- Third-Generation Cephalosporins
- ▸ ceftriaxone
- Pharmacokinetics
- ceftazidime
- Pharmacokinetics
- Fourth-Generation Cephalosporins
- cefepime
- Pharmacokinetics
- CARBAPENEMS
- Drug Profiles
- ▸ imipenem-cilastatin
- DOSAGES
- Carbapenems and Monobactams
- Pharmacokinetics
- MONOBACTAMS
- Drug Profiles
- aztreonam
- Pharmacokinetics
- MACROLIDES AND KETOLIDES
- Mechanism of Action and Drug Effects
- Table 37-7 Erythromycin Formulations
- Indications
- Table 37-8 Macrolides: Reported Adverse Effects
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ erythromycin
- ▸ azithromycin and clarithromycin
- DOSAGES
- Selected Macrolides and Ketolides
- Table 37-9 Erythromycin Dosage Forms and Product Names
- Pharmacokinetics
- telithromycin
- Pharmacokinetics
- TETRACYCLINES
- Table 37-10 Available Tetracycline Antibiotics
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- DOSAGES
- Selected Tetracyclines
- demeclocycline
- Pharmacokinetics
- ▸ doxycycline
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CASE STUDY
- Antibiotic Therapy
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 38 Antibiotics Part 2
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- AMINOGLYCOSIDES
- Table 38-1 Availability of Aminoglycoside Antibiotics
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 38-2 Aminoglycosides: Comparative Spectra of Antimicrobial Activity
- Interactions
- Dosages
- Drug Profiles
- amikacin
- Pharmacokinetics
- ▸ gentamicin
- Pharmacokinetics
- DOSAGES
- Selected Aminoglycosides
- tobramycin
- Pharmacokinetics
- neomycin
- Pharmacokinetics
- FLUOROQUINOLONES
- Mechanism of Action and Drug Effects
- Indications
- Box 38-1 Overview of Quinolone-Susceptible Microbial Spectra
- Table 38-3 Quinolones: Common Indications for Specific Drugs
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Table 38-4 Quinolones: Reported Adverse Effects
- Drug Profiles
- Quinolones
- ▸ ciprofloxacin
- Pharmacokinetics
- levofloxacin
- Pharmacokinetics
- Miscellaneous Antibiotics
- ▸ clindamycin
- DOSAGES
- Selected Fluoroquinolones (“Quinolones”)
- DOSAGES
- Selected Miscellaneous Antibiotics
- Pharmacokinetics
- dapsone
- Pharmacokinetics
- linezolid
- Pharmacokinetics
- ▸ metronidazole
- Pharmacokinetics
- nitrofurantoin
- Pharmacokinetics
- quinupristin and dalfopristin
- Pharmacokinetics
- ▸ vancomycin
- Pharmacokinetics
- daptomycin
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- EVALUATION
- Patient Teaching Tips
- Aminoglycosides
- Fluoroquinolones
- Clindamycin
- Vancomycin
- Dapsone
- Linezolid
- Metronidazole Hydrochloride
- Nitrofurantoin
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 39 Antiviral Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- GENERAL PRINCIPLES OF VIROLOGY
- FIGURE 39-1 Virus replication. Some viruses integrate into host chromosome with development of latency. (Modified from Brody TM, Larner J, Minneman KP: Human pharmacology: molecular to clinical, ed 3, St Louis, 1998, Mosby.)
- OVERVIEW OF VIRAL ILLNESSES AND THEIR TREATMENT
- Table 39-1 Examples of Nucleoside Analog Antiviral Drugs
- Table 39-2 Examples of Non-Nucleoside Analog Antiviral Drugs
- OVERVIEW OF HERPES SIMPLEX VIRUSES AND VARICELLA-ZOSTER VIRUS INFECTION
- Herpes Simplex Viruses
- Table 39-3 Antiviral Drugs: Viral Spectra, Indications, and Therapeutic Effects
- Table 39-4 Selected Antiviral Drugs: Adverse Effects
- Box 39-1 Selected Antiviral Drugs: Interactions
- Acyclovir with the Following
- Amantadine with the Following
- Didanosine with the Following
- Ganciclovir with the Following
- Indinavir with the Following
- Nevirapine with the Following
- Zalcitabine with the Following
- Zidovudine with the Following
- Varicella Zoster Virus
- ANTIVIRAL DRUGS (NONRETROVIRAL)
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- PPREVENTING MEDICATION ERRORS
- Look-Alike Drugs: Zostrix and Zovirax
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Nonretroviral Antiviral Drugs
- amantadine and rimantadine
- Pharmacokinetics
- ▸ acyclovir
- Pharmacokinetics
- ▸ ganciclovir
- DOSAGES
- Antiviral Drugs (Nonretroviral)
- Pharmacokinetics
- oseltamivir and zanamivir
- Pharmacokinetics (zanamivir)
- Pharmacokinetics (oseltamivir)
- ribavirin
- Pharmacokinetics
- OVERVIEW OF HIV INFECTION AND THE AIDS PANDEMIC
- FIGURE 39-2 Human immunodeficiency virus (HIV). Within the core capsid, the diploid, single-stranded, positive-sense RNA is complexed to nucleoprotein. (From Dorland’s illustrated medical dictionary, ed 30, Philadelphia, 2003, Saunders.)
- FIGURE 39-3 Life cycle of the HIV virus. The extracellular envelope protein gp120 binds to CD4 on the surface of T lymphocytes or mononuclear phagocytes, while the transmembrane protein gp41 mediates the fusion of the viral envelope with the cell membrane. gp, Glycoprotein. (From Dorland’s illustrated medical dictionary, ed 30, Philadelphia, 2003, Saunders.)
- Box 39-2 Epidemiology of HIV Infection
- Disease Viral Factors
- Transmission
- Who Is At Risk?
- Geographic Factors
- Modes of Control
- Box 39-3 Indicator Diseases of AIDS
- Opportunistic Infections
- Protozoal
- Fungal
- Viral
- Bacterial
- Opportunistic Neoplasias
- Others
- FIGURE 39-4 Natural history of HIV infection in the absence of therapy in a hypothetical patient. (From Fauci AS, Pantaleo G, Stanley S, Weissman D: Immunopathogenic mechanisms of HIV infection. Ann Intern Med 1996; 124:654-663. In Mandell GL, Bennett JE, Dolin R: Principles and practice of infectious diseases, ed 6, Philadelphia, 2005, Churchill Livingstone.)
- ANTIRETROVIRAL DRUGS
- Mechanism of Action and Drug Effects
- Table 39-5 Recommendations for Occupational HIV Exposure Chemoprophylaxis
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- enfuvirtide
- Pharmacokinetics
- ▸ indinavir
- Pharmacokinetics
- ▸ nevirapine
- Pharmacokinetics
- tenofovir
- Pharmacokinetics
- ▸ zidovudine
- Pharmacokinetics
- DOSAGES
- Antiretroviral Drugs
- OTHER SIGNIFICANT VIRAL ILLNESSES OF RECENT CONCERN
- NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- CASE STUDY
- Antiviral Therapy
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 40 Antitubercular Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- TUBERCULOSIS
- ANTITUBERCULAR DRUGS
- Box 40-1 First- and Second-Line Antitubercular Drugs
- First-Line Drugs
- Second-Line Drugs
- Box 40-2 Miscellaneous TB-related Injections
- Table 40-1 Antitubercular Drugs: Mechanisms of Action
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 40-2 Antitubercular Drugs: Indications
- Adverse Effects
- Interactions
- Table 40-3 Antitubercular Drugs: Common Adverse Effects
- Table 40-4 Antitubercular Drugs: Drug Interactions
- Dosages
- Drug Profiles
- ethambutol
- Pharmacokinetics
- ▸ isoniazid
- DOSAGES
- Selected Antitubercular Drugs
- Pharmacokinetics
- pyrazinamide
- Pharmacokinetics
- rifabutin
- Pharmacokinetics
- rifampin
- Pharmacokinetics
- rifapentine
- Pharmacokinetics
- streptomycin
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- CASE STUDY Tuberculosis
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 41 Antifungal Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- FUNGAL INFECTIONS
- Table 41-1 Mycotic Infections
- ANTIFUNGAL DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Box 41-1 Fungal Species That Are Susceptible to Current Antifungal Drugs
- Cutaneous and Subcutaneous Mycoses
- Systemic Mycoses
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ amphotericin B
- Pharmacokinetics*
- caspofungin
- Pharmacokinetics
- ▸ fluconazole
- Pharmacokinetics
- nystatin
- Pharmacokinetics
- terbinafine
- Table 41-2 Selected Antifungal Drugs: Common Adverse Effects and Cautions
- Table 41-3 Antifungal Drugs: Drug Interactions
- DOSAGES
- Selected Antifungal Drugs
- Pharmacokinetics
- voriconazole
- Pharmacokinetics
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 42 Antimalarial, Antiprotozoal, and Anthelmintic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- MALARIA
- FIGURE 42-1 Life cycle of the malarial parasite. (From McKenry LM, Salerno E: Mosby’s pharmacology in nursing—revised and updated, ed 21, St Louis, 2003, Mosby.)
- ANTIMALARIAL DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Table 42-1 Antimalarial Drugs: Common Adverse Effects
- Table 42-2 Antimalarial Drugs: Drug Interactions
- Drug Profiles
- ▸ chloroquine and hydroxychloroquine
- Pharmacokinetics
- mefloquine
- Pharmacokinetics
- ▸ primaquine
- DOSAGES
- Selected Antimalarial Drugs
- Table 42-3 Types of Protozoal Infections and Common Drug Therapy
- Pharmacokinetics
- pyrimethamine
- Pharmacokinetics
- OTHER PROTOZOAL INFECTIONS
- ANTIPROTOZOAL DRUGS
- Mechanism of Action and Drug Effects
- Table 42-4 Selected Antiprotozoal Drugs: Mechanisms of Action
- Indications
- Contraindications
- Table 42-5 Indications for Selected Antiprotozoal Drugs
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- atovaquone
- Pharmacokinetics
- iodoquinol
- Table 42-6 Adverse Effects for Selected Antiprotozoal Drugs
- Table 42-7 Antiprotozoal Drugs: Drug and Laboratory Test Interactions
- DOSAGES
- Selected Antiprotozoal Drugs
- Pharmacokinetics
- ▸ metronidazole
- Pharmacokinetics
- paromomycin
- Pharmacokinetics
- pentamidine
- Pharmacokinetics
- HELMINTHIC INFECTIONS
- Table 42-8 Helminthic Infections
- Table 42-9 Anthelmintics: Class of Worms Killed
- ANTHELMINTIC DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- diethylcarbamazine
- Pharmacokinetics
- Table 42-10 Anthelmintics: Mechanisms of Action
- Table 42-11 Anthelmintics: Indications
- Table 42-12 Anthelmintics: Common Adverse Effects
- ▸ mebendazole
- Pharmacokinetics
- praziquantel
- Pharmacokinetics
- pyrantel
- Pharmacokinetics
- DOSAGES
- Selected Anthelmintic Drugs
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 43 Antiseptic and Disinfectant Agents
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- COMMUNITY-ACQUIRED AND NOSOCOMIAL INFECTIONS
- Table 43-1 Changing Prevalence of Nosocomial Pathogens
- TOPICAL ANTIMICROBIALS
- Mechanism of Action and Effects of Antiseptics and Disinfectants
- Table 43-2 Antiseptics Versus Disinfectants
- Table 43-3 Disinfectants and Antiseptics: Chemical Categories
- Table 43-4 Antiseptics and Disinfectants: Mechanisms of Action
- Table 43-5 Antiseptics and Disinfectants: Therapeutic Effects
- Indications
- Table 43-6 Antiseptic and Disinfectant Agents: Adverse Effects
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- Acid Agents
- Alcohol Agents
- Aldehyde Agents
- Biguanide Agents
- Dyes
- Chlorine Compounds
- DOSAGES
- Selected Antiseptic and Disinfectant Agents
- Mercurial Agents
- Iodine Compounds
- Oxidizing Agents
- Phenolic Compounds
- Surface-Active Agents
- Table 43-7 Iodine Formulations
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 44 Antiinflammatory, Antirheumatic, and Related Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- CASE STUDY
- Postoperative Pain
- ARACHIDONIC ACID PATHWAY
- NONSTEROIDAL ANTIINFLAMMATORY DRUGS
- Mechanism of Action and Drug Effects
- FIGURE 44-1 Arachidonic acid pathway.
- Box 44-1 Chemical Categories of NSAIDs
- Acetic Acids
- Carboxylic Acids
- Acetylated
- Nonacetylated
- COX-2 Inhibitors
- Fenamic Acids
- Napthylalkanones (Nonacidic)
- Oxicams
- Propionic Acids
- Box 44-2 NSAIDs: FDA-Approved Indications
- Indications
- Table 44-1 Suggested NSAIDs for Patients with Various Medical Conditions
- Contraindications
- Adverse Effects
- Table 44-2 NSAIDs: Adverse Effects
- Toxicity and Management of Overdose
- Table 44-3 Acute or Chronic Salicylate Intoxication: Signs and Symptoms
- Table 44-4 Acute Salicylate Intoxication: Treatment
- Table 44-5 Acute Salicylate Intoxication: Treatment Goals
- Table 44-6 Salicylates and Other NSAIDs: Drug Interactions
- Interactions
- DOSAGES
- Most Commonly Used NSAIDs
- Dosages
- Drug Profiles
- Nonsteroidal Antiinflammatory Drugs
- Acetic Acids
- ▸ aspirin
- Pharmacokinetics
- ▸ indomethacin
- Pharmacokinetics
- Propionic Acids
- ▸ ibuprofen
- Pharmacokinetics
- Pyrrolizine Carboxylic Acids
- ▸ ketorolac
- Pharmacokinetics
- COX-2 Inhibitors
- ▸ celecoxib
- Pharmacokinetics
- ENOLIC ACIDS, FENAMIC ACIDS, AND NONACIDIC COMPOUNDS
- ANTIRHEUMATIC DRUGS
- FIGURE 44-2 Uric acid production. XO, Xanthine oxidase.
- Drug Profiles
- Antigout Drugs
- ▸ allopurinol
- colchicine
- probenecid and sulfinpyrazone
- Antirheumatoid Arthritis Drugs
- auranofin
- aurothioglucose and gold sodium thiomalate
- leflunomide
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Herbal Therapies and Dietary Supplements
- Glucosamine and Chondroitin
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Lifespan Considerations: The Pediatric Patient
- Reye’s Syndrome
- Signs and Symptoms
- Medical Management
- Nursing Management
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 8 Immune and Biologic Modifiers and Chemotherapeutic Drugs
- Immune and Biologic Modifiers and Chemotherapeutic Drugs
- STUDY SKILLS TIPS
- TIME MANAGEMENT
- EVALUATE PRIOR PERFORMANCE
- What Type of Errors Did I Make?
- Did I Have Trouble with Questions That Required Mastery of Terminology?
- Did I Miss Concept Questions?
- Did I Make Errors Because I Did not Know the Material?
- ANTICIPATE THE TEST
- PLAN FOR DISTRIBUTED STUDY
- CHAPTER 45 Immunosuppressant Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- IMMUNOSUPPRESSANT DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Table 45-1 Classification, Mechanisms of Action, and Indications for Available Immunosuppressant Drugs
- Contraindications
- Adverse Effects
- Table 45-2 Selected Immunosuppressant Drugs: Common Adverse Effects
- Interactions
- Dosages
- DOSAGES
- Selected Immunosuppressant Drugs
- Drug Profiles
- ▸ azathioprine and mycophenolate mofetil
- Pharmacokinetics (azathioprine)
- Pharmacokinetics (mycophenolate mofetil)
- basiliximab and daclizumab
- Pharmacokinetics(basiliximab)
- Pharmacokinetics(daclizumab)
- ▸ cyclosporine
- Pharmacokinetics*
- glatiramer acetate
- ▸ muromonab-CD3
- Pharmacokinetics
- sirolimus and tacrolimus
- Pharmacokinetics(sirolimus)
- Pharmacokinetics(sirolimus)
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 46 Immunizing Drugs and Biochemical Terrorism
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- IMMUNITY AND IMMUNIZATION
- Table 46-1 Active Versus Passive Immunization
- ACTIVE IMMUNIZATION
- Toxoids
- Vaccines
- PASSIVE IMMUNIZATION
- Box 46-1 Available Immunizing Drugs
- Passively Immunizing Drugs
- Actively Immunizing Drugs
- FIGURE 46-1 Recommended childhood immunization schedule. ACIP, Advisory Committee on Immunization Practices; DTP, diphtheria, tetanus, and pertussis vaccine; HBsAG, hepatitis B surface antigen; Tdap, tetanus and diphtheria toxoids and acellular pertussis vaccine. (From Centers for Disease Control and Prevention, National Immunization Program: Recommended childhood and adolescent immunization schedule: United States: 2006. Available at www.cdc.gov/nip/recs/child-schedule-color-print.pdf.)
- IMMUNIZING DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Table 46-2 Immunizing Drugs: Minor and Severe Adverse Effects
- Interactions
- Table 46-3 Vaccine Injury Table
- Dosages
- Drug Profiles
- Active Immunizing Drugs
- diphtheria and tetanus toxoids, and acellular pertussis vaccine (adsorbed)
- Haemophilus Influenzae Type b conjugate vaccine
- ▸ hepatitis B virus vaccine (inactivated)
- ▸ influenza virus vaccine
- DOSAGES
- Selected Immunizing Drugs
- ▸ measles, mumps, and rubella virus vaccine (live)
- ▸ pneumococcal vaccine, polyvalent and seven-valent
- ▸ poliovirus vaccine (inactivated)
- rabies virus vaccine
- ▸ varicella virus vaccine
- Passive Immunizing Drugs
- ▸ hepatitis B immunoglobulin
- ▸ immunoglobulin
- Box 46-2 Current FDA-Approved Uses of Immunoglobulins*
- Rh0(D) immunoglobulin
- rabies immunoglobulin
- tetanus immunoglobulin
- varicella-zoster immunoglobulin
- BIOLOGIC AND CHEMICAL TERRORISM
- ANTHRAX
- Table 46-4 Illnesses Caused by CDC Category “A” Possible Bioterrorism Agents*
- Table 46-5 Possible Chemical Terrorism Agents
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 47 Antineoplastic Drugs Part 1: Cancer Overview and Cell Cycle–Specific Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- FIGURE 47-1 Schematic model of multistep carcinogenesis. Genetic change refers to events such as the activation of protooncogenes or drug-resistance genes or the inactivation of tumor suppressor genes, antimetastasis genes, or apoptosis (normal cell death). Genetic change may be relatively minimal, as with the translocations seen in various leukemias, or it may involve multiple sequential genetic alterations, as exemplified by the development of colon cancer. (From Haskell CM: Cancer treatment, ed 5, Philadelphia, 2001, Saunders.)
- Table 47-1 Tumor Characteristics: Benign and Malignant
- Table 47-2 Tumor Classification Based on Specific Tissue of Origin
- Table 47-3 Paraneoplastic Syndromes Associated with Some Cancers
- ETIOLOGY OF CANCER
- AGE- AND SEX-RELATED DIFFERENCES
- Table 47-4 Cancer: Proposed Etiologic Factors
- GENETIC AND ETHNIC FACTORS
- ONCOGENIC VIRUSES
- OCCUPATIONAL AND ENVIRONMENTAL CARCINOGENS
- RADIATION
- IMMUNOLOGIC FACTORS
- Table 47-5 Common Names for Selected Cell Cycle–Specific Antineoplastic Drugs
- CANCER DRUG NOMENCLATURE
- CELL GROWTH CYCLE
- Table 47-6 Cell Cycle Phases
- FIGURE 47-2 General phase of the cell cycle in which the various cell cycle–specific chemotherapeutic drugs have their greatest proportionate kill of cancer cells.
- DRUG THERAPY
- FIGURE 47-3 Gompertzian tumor growth curve showing the relationship between tumor size and clinical status. (From Lehne RA: Pharmacology for nursing care, ed 6, St Louis, 2007, Saunders.)
- FIGURE 47-4 Relationship of tumor burden to treatment strategies and outcome with systemic chemotherapy. Human tumors grow in accordance with the Gompertz curve (dashed line), with a decreasing doubling time as tumor burden increases. Treatment interventions relate to tumor type and extent of disease. A, Surgery followed by pulse courses of adjuvant chemotherapy. Combined modality has curative potential with the addition of chemotherapy after surgery. B, Systemic chemotherapy for stage III Hodgkin’s disease. Cure is possible with prolonged administration of combination chemotherapy. C, Palliative chemotherapy for advanced non–small cell cancer. The patient’s tumor burden is too great, and the potency of the drugs for this specific form of cancer too inadequate because of the development of drug resistance, to allow cure. (Modified from Salmon SE, Sartorelli AC: Cancer chemotherapy. In Katzung BG, editor: Basic and clinical pharmacology, ed 4, Norwalk, Conn, 1989, Appleton & Lange, p. 685.)
- Box 47-1 Relative Emetic Potential of Selected Antineoplastic Drugs*
- Low (Less Than 10% to 30%)
- Moderate (30% to 60%)
- High (60% to More Than 90%)
- CELL CYCLE–SPECIFIC ANTINEOPLASTIC DRUGS
- ANTIMETABOLITES
- Mechanism of Action and Drug Effects
- Folic Acid Antagonism
- Purine Antagonism
- Pyrimidine Antagonism
- Indications
- Adverse Effects
- Table 47-7 Common Manifestations of Antineoplastic Toxicity
- Table 47-8 Selected Antimetabolites: Common Drug-Specific Adverse Effects
- Table 47-9 Selected Antimetabolites: Common Drug Interactions
- Interactions
- Dosages
- Drug Profiles
- Folate Antagonists
- ▸ methotrexate
- Purine Antagonists
- cladribine
- fludarabine
- Pyrimidine Antagonists
- capecitabine
- DOSAGES
- Selected Antimetabolites
- ▸ cytarabine
- fluorouracil
- gemcitabine
- MITOTIC INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Adverse Effects
- Table 47-10 Selected Mitotic Inhibitors: Adverse Effects
- Toxicity: Management of Extravasation
- Interactions
- Dosages
- Drug Profiles
- ▸ etoposide
- ▸ paclitaxel
- Table 47-11 Mitotic Inhibitor Extravasation: Listed Specific Antidotes
- Table 47-12 Selected Mitotic Inhibitors: Common Drug Interactions
- DOSAGES
- Selected Mitotic Inhibitors
- ▸ vincristine
- TOPOISOMERASE I INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Adverse Effects
- Table 47-13 Irinotecan: Common Drug Interactions
- Interactions
- Dosages
- Drug Profiles
- irinotecan
- topotecan
- ANTINEOPLASTIC ENZYMES
- DOSAGES
- Selected Topoisomerase I Inhibitors
- Indications
- Adverse Effects
- Table 47-14 Selected Antineoplastic Enzymes: Common Drug Interactions
- Interactions
- Dosages
- Drug Profiles
- ▸ asparaginase
- pegaspargase
- DOSAGES
- Selected Antineoplastic Enzymes
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Antineoplastic Therapy: Rationales for Assessment and Monitoring of Blood Cell Counts
- Box 47-2 Effects of Antineoplastic Drugs on Normal Cells and Related Adverse Effects
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CASE STUDY
- Facing Chemotherapy
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 48 Antineoplastic Drugs Part 2: Cell Cycle–Nonspecific and Miscellaneous Drugs
- Objectives
- e-Learning Activities
- Companion CD
- Evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- Table 48-1 Common Names for Selected Antineoplastic Drugs
- CELL CYCLE–NONSPECIFIC ANTINEOPLASTIC DRUGS
- ALKYLATING DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Adverse Effects
- Interactions
- FIGURE 48-1 Deoxyribonucleic acid (DNA) double helix. A, Diagrammatic model of the helical structure, showing its dimensions, the major and minor grooves, the periodicity of the bases, and the antiparallel orientation of the backbone chains (represented by ribbons). The base pairs (represented by rods) are perpendicular to the axis and lie stacked one on another. B, The chemical structure of the backbone and bases of DNA, showing the sugar-phosphate linkages of the backbone and the hydrogen bonding between the base pairs. There are two hydrogen bonds between adenine and thymine, and three between cytosine and guanine. (From Dorland’s illustrated medical dictionary, ed 30, Philadelphia, 2003, Saunders.)
- FIGURE 48-2 Organization of deoxyribonucleic acid (DNA) and site of action of alkylating drugs.
- Table 48-2 Commonly Used Alkylating Drugs: Severe Adverse Effects
- Box 48-1 Extravasation of Antineoplastics
- Table 48-3 Alkylating Drug Extravasation: Specific Antidotes
- Dosages
- Drug Profiles
- ▸ cisplatin
- ▸ cyclophosphamide
- DOSAGES
- Selected Alkylating Drugs
- ▸ mechlorethamine
- CYTOTOXIC ANTIBIOTICS
- Preventing Medication Errors
- Sound-Alike Drugs: “Rubicins”
- Mechanism of Action and Drug Effects
- Table 48-4 Cytotoxic Antibiotics: Severe Adverse Effects
- Box 48-2 Treatment of Doxorubicin Extravasation
- Indications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- DOSAGES
- Selected Cytotoxic Antibiotics
- Drug Profiles
- ▸ doxorubicin
- mitoxantrone
- MISCELLANEOUS ANTINEOPLASTICS
- Drug Profiles
- bevacizumab
- hydroxyurea
- imatinib
- mitotane
- octreotide
- HORMONAL ANTINEOPLASTICS
- RADIOPHARMACEUTICALS AND RELATED ANTINEOPLASTICS
- CYTOPROTECTIVE DRUGS AND MISCELLANEOUS TOXICITY INHIBITORS
- Box 48-3 Concerns in the Handling and Administration of Vesicant Antineoplastic Drugs
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- LABORATORY VALUES RELATED TO DRUG THERAPY
- Antineoplastics
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Box 48-4 Indications of an Oncologic Emergency
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 49 Biologic Response–Modifying Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- OVERVIEW OF IMMUNOMODULATORS
- IMMUNE SYSTEM
- Humoral Immune System
- Cell-Mediated Immune System
- FIGURE 49-1 Cells of the humoral (antibody-mediated) immune system. Ab, Antibody; Ag, antigen; Ig, immunoglobulin.
- FIGURE 49-2 Cells of the cellular immune system.
- Box 49-1 Biologic Response Modifiers
- Hematopoietic Drugs
- Colony-Stimulating Factors
- Other
- Immunomodulating Drugs
- Interferons
- Monoclonal Antibodies
- Interleukin Receptor Agonists and Antagonists
- Miscellaneous Immunomodulators
- HEMATOPOIETIC DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 49-1 Hematopoietic Drugs: Common Adverse Effects
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ epoetin alfa
- DOSAGES
- Hematopoietic Drugs
- Pharmacokinetics
- ▸ filgrastim
- Pharmacokinetics
- ▸ sargramostim
- Pharmacokinetics
- ▸ oprelvekin
- Pharmacokinetics
- INTERFERONS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 49-2 Interferons: Adverse Effects
- Dosages
- Drug Profiles
- Interferon Alfa Products
- ▸ interferon alfa-2a, interferon alfa-2b, interferon alfa-n3, interferon alfacon-1, peginterferon alfa-2a, peginterferon alfa-2b
- DOSAGES
- Interferons
- Interferon Beta Products
- ▸ interferon beta-1a
- Interferon Gamma Products
- interferon gamma-1b
- MONOCLONAL ANTIBODIES
- Mechanism of Action, Drug Effects, and Indications
- Contraindications
- Table 49-3 Common Adverse Effects Associated with Specific Immunomodulating Drugs
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- adalimumab
- DOSAGES
- Monoclonal Antibodies
- alemtuzumab
- bevacizumab
- cetuximab
- gemtuzumab ozogamicin
- ibritumomab tiuxetan
- infliximab
- natalizumab
- ▸ rituximab
- tositumomab and iodine I 131 tositumomab
- trastuzumab
- INTERLEUKINS AND RELATED DRUGS
- Mechanism of Action and Drug Effects
- Box 49-2 Interleukin-2: Drug Effects
- Modulating Effects
- Enhancing Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- DOSAGES
- Interleukins and Related Drugs
- Dosages
- Drug Profiles
- ▸ aldesleukin
- denileukin diftitox
- anakinra
- MISCELLANEOUS IMMUNOMODULATING DRUGS
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Table 49-4 Miscellaneous Immunomodulating Drugs
- ♦ NURSING DIAGNOSES
- PLANNING
- Goals
- LEGAL AND ETHICAL PRINCIPLES
- The Nurse and Patient Care
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 50 Gene Therapy and Pharmacogenomics
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Glossary
- INTRODUCTION
- BASIC PRINCIPLES OF GENETIC INHERITANCE
- DISCOVERY, STRUCTURE, AND FUNCTION OF DNA
- Protein Synthesis
- The Human Genome Project
- GENE THERAPY
- Regulatory and Ethical Issues Regarding Gene Therapy
- FIGURE 50-1 Gene therapy for adenosine deaminase (ADA) deficiency attempts to correct this immunodeficiency state. The viral vector containing the therapeutic gene is inserted into the patient’s lymphocytes. These cells can then make the ADA enzyme. (From Lewis SM, Heitkemper MM, Dirksen SR: Medical-surgical nursing: assessment and management of clinical problems, ed 6, St Louis, 2004, Mosby.)
- PHARMACOGENOMICS
- Table 50-1 Clinical Applications of Pharmacogenomics
- SUMMARY
- Box 50-1 Application of Genetics, Genomics, and Pharmacogenomics in Nursing and Health Care
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 9 Drugs Affecting the Gastrointestinal System and Nutrition
- Drugs Affecting the Gastrointestinal System and Nutrition
- STUDY SKILLS TIPS
- ACTIVE QUESTIONING
- WHAT ARE THE RIGHT QUESTIONS?
- KINDS OF QUESTIONS
- Literal Questions
- Interpretive Questions
- QUESTIONING APPLICATION
- CHAPTER 51 Acid-Controlling Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ACID-RELATED PATHOPHYSIOLOGY
- FIGURE 51-1 The three zones of the stomach and the associated glands.
- FIGURE 51-2 Parietal cell stimulation and secretion. ADP, Adenosine diphosphate; ATP, adenosine triphosphate; ATPase, adenosine triphosphatase; cAMP, cyclic adenosine monophosphate.
- Table 51-1 Current FDA-Approved Regimens for Eradication of Helicobacter pylori
- ANTACIDS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Box 51-1 Nursing Concerns for Patients Taking Antacids
- Dosages
- Drug Profiles
- Antacids, general
- DOSAGES
- Selected Antacid Drugs*
- Box 51-2 Antacids
- Antacids: Salt Content
- Commonly Available Antacid Products
- Magnesium-Containing Antacids
- Aluminum-Containing Antacids
- Calcium-Containing Antacids
- Sodium-Containing Antacids
- H2 ANTAGONISTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 51-2 H2 Antagonists: Adverse Effects
- Dosages
- Drug Profiles
- ▸ cimetidine
- DOSAGES
- Selected H2 Antagonists
- Pharmacokinetics
- PROTON PUMP INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- DOSAGES
- Selected Proton Pump Inhibitors
- Drug Profiles
- ▸ omeprazole
- Pharmacokinetics
- MISCELLANEOUS ACID-CONTROLLING DRUGS
- Drug Profiles
- ▸ sucralfate
- Pharmacokinetics
- misoprostol
- Pharmacokinetics
- simethicone
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CASE STUDY
- Gastroesophageal Reflux Disease
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 52 Antidiarrheals and Laxatives
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ANTIDIARRHEALS
- Mechanism of Action and Drug Effects
- Table 52-1 Antidiarrheals: Drug Categories and Selected Drugs
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 52-2 Selected Antidiarrheals: Adverse Effects
- Life Span Considerations: The Pediatric Patient
- Antidiarrheal Preparations
- Dosages
- Drug Profiles
- Adsorbents
- bismuth subsalicylate
- Pharmacokinetics
- Anticholinergics
- belladonna alkaloid combinations
- DOSAGES
- Selected Antidiarrheal Drugs
- Pharmacokinetics
- Opiates
- ▸ diphenoxylate with atropine
- Pharmacokinetics*
- ▸ loperamide
- Pharmacokinetics
- Intestinal Flora Modifiers
- Lactobacillus acidophilus
- LAXATIVES
- Table 52-3 Causes of Constipation
- Mechanism of Action and Drug Effects
- Table 52-4 Laxatives: Drug Categories and Selected Drugs
- Table 52-5 Laxatives: Drug Effects
- Indications
- Table 52-6 Laxatives: Indications
- Contraindications
- Adverse Effects
- Interactions
- Table 52-7 Laxatives: Adverse Effects
- Dosages
- Drug Profiles
- Bulk-Forming Laxatives
- methylcellulose
- Pharmacokinetics
- ▸ psyllium
- Pharmacokinetics
- Emollient Laxatives
- ▸ docusate salts
- Pharmacokinetics
- mineral oil
- Pharmacokinetics
- Hyperosmotic Laxatives
- ▸ glycerin
- Pharmacokinetics
- DOSAGES
- Selected Laxatives
- ▸ lactulose
- Pharmacokinetics
- polyethylene glycol 3350
- Pharmacokinetics
- Box 52-1 Saline Laxatives
- Magnesium Laxatives
- Sulfate
- Hydroxide
- Citrate
- Sodium Laxatives
- Saline Laxatives
- magnesium salts
- Pharmacokinetics
- Stimulant Laxatives
- ▸ senna
- Pharmacokinetics
- Drugs for Irritable Bowel Syndrome
- DOSAGES
- Drugs for Irritable Bowel Syndrome
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- CASE STUDY
- Constipation
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 53 Antiemetic and Antinausea Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- NAUSEA AND VOMITING
- ANTIEMETIC DRUGS
- Life Span Considerations: The Pediatric Patient
- Syrup of Ipecac
- Mechanism of Action and Drug Effects
- Table 53-1 Neurotransmitters Involved in Nausea and Vomiting
- FIGURE 53-1 The various pathways and areas in the body sending signals to the vomiting center.
- Table 53-2 Antiemetic Drugs: Common Drug Categories
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- FIGURE 53-2 Sites of action of selected antinausea drugs. THC, Tetrahydrocannabinol.
- Table 53-3 Antiemetic Drugs: Mechanisms of Action
- Anticholinergics
- scopolamine
- Table 53-4 Antiemetic Drugs: Indications
- Pharmacokinetics
- Table 53-5 Antinausea Drugs: Adverse Effects
- Antihistamines
- ▸ meclizine
- Pharmacokinetics
- Neuroleptics
- ▸ prochlorperazine
- Pharmacokinetics
- Prokinetics
- ▸ metoclopramide
- Pharmacokinetics
- Serotonin Blockers
- ▸ ondansetron
- Pharmacokinetics
- Tetrahydrocannabinoids
- dronabinol
- DOSAGES
- Selected Antitubercular Drugs
- Pharmacokinetics
- Miscellaneous Antinausea Drugs
- phosphorated carbohydrate solution
- aprepitant
- CASE STUDY
- Nausea and Chemotherapy
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- HERBAL THERAPIES AND DIETARY SUPPLEMENTS
- Ginger (Zingiber officinale)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 54 Vitamins and Minerals
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- VITAMINS
- Table 54-1 Fat- and Water-Soluble Vitamins
- FAT-SOLUBLE VITAMINS
- VITAMIN A
- Mechanism of Action and Drug Effects
- Table 54-2 Food Sources for Selected Nutrients
- Table 54-3 Vitamin A: Adverse Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- vitamin A
- Pharmacokinetics
- VITAMIN D
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- DOSAGES
- Selected Vitamins
- Table 54-4 Vitamin D: Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- calcifediol
- Pharmacokinetics
- calcitriol
- Pharmacokinetics
- dihydrotachysterol
- Pharmacokinetics
- ergocalciferol
- Pharmacokinetics
- VITAMIN E
- Mechanism of Action and Drug Effects
- Indications
- Table 54-5 Vitamin E: Adverse Effects
- Contraindications
- Adverse Effects
- Dosages
- Drug Profiles
- vitamin E
- Pharmacokinetics
- VITAMIN K
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Table 54-6 Vitamin K: Adverse Effects
- Dosages
- Drug Profiles
- vitamin K1
- Pharmacokinetics
- WATER-SOLUBLE VITAMINS
- Box 54-1 Water-Soluble Vitamins: Alternate Names
- VITAMIN B1
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- thiamine
- Pharmacokinetics
- VITAMIN B2
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Dosages
- Drug Profiles
- riboflavin
- Pharmacokinetics
- VITAMIN B3
- Mechanism of Action and Drug Effects
- FIGURE 54-1 Niacin, once in the body, is converted to nicotinamide adenosine dinucleotide (NAD) and nicotinamide adenosine dinucleotide (NADP), which are coenzymes needed for many metabolic processes.
- Indications
- Contraindications
- Adverse Effects
- Dosages
- Table 54-7 Niacin: Adverse Effects
- Drug Profiles
- niacin
- Pharmacokinetics
- VITAMIN B6
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 54-8 Pyridoxine: Adverse Effects
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- pyridoxine
- Pharmacokinetics
- VITAMIN B12
- FIGURE 54-2 Cyanocobalamin is a required coenzyme for many body processes.
- FIGURE 54-3 The oral absorption of cyanocobalamin requires the presence of the intrinsic factor secreted by gastric parietal cells.
- Mechanism of Action and Drug Effects
- Indications
- Table 54-9 Cyanocobalamin: Adverse Effects
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- cyanocobalamin
- Pharmacokinetics
- VITAMIN C
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ascorbic acid
- Pharmacokinetics
- MINERALS
- FIGURE 54-4 When mineral compounds are dissolved in water, they separate into positively charged metabolic cations or negatively charged nonmetallic anions and electrolytes.
- Table 54-10 Mineral Elements
- CALCIUM
- Table 54-11 Calcium Deficiency: Causes and Disorders
- Mechanism of Action and Drug Effects
- Indications
- Table 54-12 Calcium Salts: Calcium Content
- Table 54-13 Calcium Salts: Adverse Effects
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Drug Profiles
- calcium
- MAGNESIUM
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Drug Profiles
- magnesium
- PHOSPHORUS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Drug Profiles
- phosphorus
- ZINC
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- CASE STUDY
- Magnesium Sulfate Therapy
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 55 Nutrition Supplements
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ENTERAL NUTRITION
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- FIGURE 55-1 Tube feeding routes. (From Beare PG, Myers JL: Adult health nursing, ed 3, St Louis, 1998, Mosby.)
- Table 55-1 Routes of Enteral Nutrition Delivery
- Adverse Effects
- Interactions
- Box 55-1 Enteral Formulations
- Box 55-2 Enteral Nutrition Supplements: Indications
- Complete Nutrition Formulations (i.e., for General Nutrition Deficiencies)
- Incomplete Nutrition Formulations (i.e., for Specific Nutrition Deficiencies)
- Infant Nutrition Formulations
- Dosages
- Drug Profiles
- Elemental Formulations
- Polymeric Formulations
- Modular Formulations
- carbohydrate formulation
- fat formulation
- protein formulation
- Altered Amino Acid Formulations
- PARENTERAL NUTRITION
- Table 55-2 Peripheral and Central Parenteral Nutrition: Characteristics
- PERIPHERAL TOTAL PARENTERAL NUTRITION
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 55-3 Amino Acids: Recommended Daily Dosage Guidelines
- Adverse Effects
- Dosages
- Drug Profiles
- Amino Acids
- amino acids
- Box 55-3 Enteral Formulations
- Essential
- Nonessential
- Semiessential
- FIGURE 55-2 One gram of dextrose, fat, or protein will provide varying amounts of energy as calories.
- carbohydrates
- fat
- FIGURE 55-3 Lipid emulsions supply essential fatty acids and energy.
- lipid emulsions
- TRACE ELEMENTS
- CENTRAL TOTAL PARENTERAL NUTRITION
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Dosages
- Drug Profiles
- NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- PART 10 Miscellaneous Therapeutics: Hematologic, Dermatologic, Ophthalmic, and Otic Drugs
- Miscellaneous Therapeutics: Hematologic, Dermatologic, Ophthalmic, and Otic Drugs
- STUDY SKILLS TIPS
- TIME MANAGEMENT
- Goal Statements
- Action Planning
- Action Steps Example
- PURR
- Prepare Example
- Outline Example
- REPEAT THE STEPS
- CHAPTER 56 Blood-Forming Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- ERYTHROPOIESIS
- FIGURE 56-1 Schematic structure of a hemoglobin molecule.
- FIGURE 56-2 Underlying causes of anemia are RBC maturation defects and factors secondary to excessive RBC destruction. RBC, Red blood cell.
- FIGURE 56-3 Schematic showing common causes and results of RBC cytoplasmic maturation defects.
- TYPES OF ANEMIA
- FIGURE 56-4 Schematic showing common causes and results of RBC nuclear maturation defects.
- FIGURE 56-5 Increased red blood cell destruction occurs as a result of intrinsic and extrinsic factors. DIC, Disseminated intravascular coagulation; G6PD, glucose-6-phosphate dehydrogenase; RBC, red blood cell.
- IRON
- Mechanism of Action and Drug Effects
- Table 56-1 Ferrous Salts: Iron Content
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Table 56-2 Iron Preparations: Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ ferrous fumarate
- Pharmacokinetics
- Pharmacokinetics
- FOLIC ACID
- Mechanism of Action and Drug Effects
- DOSAGES
- Selected Iron Preparations and Folic Acid
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ folic acid
- Pharmacokinetics
- OTHER BLOOD-FORMING DRUGS
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Life Span Considerations: The Elderly Patient
- Iron Products
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 57 Dermatologic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- FIGURE 57-1 A microscopic view of the skin. The epidermis, shown in longitudinal section, is raised at one corner to reveal the ridges in the dermis. (Modified from Thibodeau GA, Patton KT: Anatomy and physiology, ed 5, St. Louis, 2003, Mosby.)
- SKIN ANATOMY AND PHYSIOLOGY
- Table 57-1 Epidermal Layers
- Table 57-2 Exocrine Glands of the Skin
- TOPICAL DERMATOLOGIC DRUGS
- ANTIMICROBIALS
- Drug Profiles
- General Antibacterial Drugs
- Table 57-3 Dermatologic Formulations: Characteristics and Examples
- ▸ bacitracin
- neomycin and polymyxin B
- mupirocin
- ▸ silver sulfadiazine
- EVIDENCE-BASED PRACTICE
- Antiseptics and Wound Care
- Review
- Type of Evidence and Research
- Results of Study
- Link of Evidence to Nursing Practice
- Anti-Acne Drugs
- ▸ benzoyl peroxide
- clindamycin
- ▸ isotretinoin
- tretinoin
- Antifungal Drugs
- ▸ clotrimazole
- miconazole
- Table 57-4 Topical Antifungal Drugs
- Antiviral Drugs
- ANESTHETIC, ANTIPRURITIC, AND ANTIINFLAMMATORY DRUGS
- TOPICAL ANESTHETICS
- TOPICAL ANTIPRURITICS
- Table 57-5 Commonly Used Topical Corticosteroids (in Order of Decreasing Potency)
- ANTIPSORIATIC DRUGS
- Drug Profiles
- tazarotene
- tar-containing products
- anthralin
- calcipotriene
- MISCELLANEOUS DERMATOLOGIC DRUGS
- Drug Profiles
- Ectoparasiticidal Drugs
- Herbal Therapies and Dietary Supplements
- Aloe (Aloe vera L.)
- Overview
- Common Uses
- Adverse Effects
- Potential Drug Interactions
- Contraindications
- ▸ lindane
- Hair Growth Drugs
- minoxidil
- Sunscreens
- Antineoplastic Drugs
- fluorouracil
- Immunomodulators
- ▸ pimecrolimus
- imiquimod
- WOUND CARE DRUGS
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- Table 57-6 Selected Wound-Care Products
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 58 Ophthalmic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- OCULAR ANATOMY AND PHYSIOLOGY
- FIGURE 58-1 A horizontal section through the left eyeball, looking from the top down. (Modified from Thibodeau GA, Patton KT: Anatomy and physiology, ed 5, St Louis, 2003, Mosby.)
- FIGURE 58-2 Extrinsic muscles of the right eye. Lateral view. (Modified from Thibodeau GA, Patton KT: Anatomy and physiology, ed 5, St Louis, 2003, Mosby.)
- LACRIMAL GLANDS
- LAYERS OF THE EYE
- FIGURE 58-3 Different nervous systems control pupil size.
- FIGURE 58-4 Drug classes and their effects on pupil size.
- FIGURE 58-5 Function of rods and cones in relation to color vision.
- FIGURE 58-6 Main structures of the eye and an enlargement of the canal of Schlemm showing an aqueous flow. A, Normal eye. B, In angle-closure glaucoma, the closure of the anterior angle prevents aqueous humor from exiting through the canal of Schlemm, leading to increased intraocular pressure. C, In open-angle glaucoma, the anterior angle remains open, but the canal of Schlemm is obstructed by tissue abnormalities. (Modified from McKenry LM, Salerno E: Mosby’s pharmacology in nursing—revised and updated, ed 21, St Louis, 2003, Mosby.)
- OCULAR DRUGS
- ANTIGLAUCOMA DRUGS
- Table 58-1 Glaucoma: Types and Characteristics
- FIGURE 58-7 How increased aqueous humor can result in impaired vision. IOP, Intraocular pressure.
- Table 58-2 Antiglaucoma Drug Effects on Aqueous Humor
- CHOLINERGIC DRUGS
- Mechanism of Action and Drug Effects
- FIGURE 58-8 The therapeutic effects of direct- and indirect-acting parasympathomimetics on glaucoma. IOP, Intraocular pressure.
- FIGURE 58-9 Cholinergic response of miosis to parasympathomimetics. ACh, Acetylcholine; AChE, acetylcholinesterase; PSNS, parasympathetic nervous system.
- FIGURE 58-10 Metabolism of acetylcholine by endogenous enzymes.
- Indications
- Contraindications
- Adverse Effects
- Table 58-3 Miotics: Indications
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Table 58-4 Miotics: Adverse Effects
- Drug Profiles
- Direct-Acting Miotics
- acetylcholine
- Pharmacokinetics
- ▸ pilocarpine
- Pharmacokinetics (Immediate-Release Formulation)
- Indirect-Acting Miotics
- ▸ echothiophate and demecarium
- Pharmacokinetics
- DOSAGES
- Selected Miotics
- SYMPATHOMIMETICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- FIGURE 58-11 Mechanism of mydriasis.
- FIGURE 58-12 Ocular effects of alpha (a) and beta (b) stimulation. IOP, Intraocular pressure.
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- apraclonidine
- DOSAGES
- Selected Ocular Sympathomimetics
- Pharmacokinetics
- ▸ dipivefrin
- Pharmacokinetics
- β-ADRENERGIC BLOCKERS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- Drug Profiles
- ▸ betaxolol
- DOSAGES
- Selected Ocular β-Blockers
- Pharmacokinetics
- ▸ timolol
- Pharmacokinetics
- CARBONIC ANHYDRASE INHIBITORS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 58-5 Carbonic Anhydrase Inhibitors: Adverse Effects
- Adverse Effects
- Toxicity and Management of Overdose
- Interactions
- Dosages
- DOSAGES
- Ocular Carbonic Anhydrase Inhibitors
- Drug Profiles
- ▸ dorzolamide
- Pharmacokinetics
- OSMOTIC DIURETICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Toxicity and Management of Overdose
- Dosages
- Drug Profiles
- glycerin
- Pharmacokinetics
- mannitol
- FIGURE 58-13 Mechanism and ocular effects of osmotic diuretics. IOP, Intraocular pressure.
- Table 58-6 Osmotic Diuretics: Adverse Effects
- DOSAGES
- Osmotic Diuretics
- Pharmacokinetics
- PROSTAGLANDIN AGONISTS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Dosages
- Drug Profiles
- ▸ latanoprost
- DOSAGES
- Prostaglandin Agonists
- Pharmacokinetics
- ANTIMICROBIAL DRUGS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Table 58-7 Common Ocular Infections
- Adverse Effects
- Interactions
- Dosages
- DOSAGES
- Selected Ocular Antimicrobials
- Drug Profiles
- ANTIBACTERIAL DRUGS
- Aminoglycosides
- ▸ gentamicin
- Pharmacokinetics
- Macrolides
- ▸ erythromycin
- Pharmacokinetics
- Polypeptides
- ▸ bacitracin
- Pharmacokinetics
- Quinolones
- ▸ ciprofloxacin
- Pharmacokinetics
- Sulfonamides
- ▸ sulfacetamide
- Pharmacokinetics
- Antifungal Drugs
- natamycin
- Pharmacokinetics
- ANTIVIRALS
- ganciclovir and fomivirsen
- trifluridine
- ANTIINFLAMMATORY DRUGS
- Box 58-1 Ophthalmic Antiinflammatory Drugs
- NSAIDs
- Corticosteroids
- Mechanism of Action and Drug Effects
- FIGURE 58-14 Antiinflammatory action of corticosteroids and nonsteroidal antiinflammatory drugs (NSAIDs).
- Indications
- Contraindications
- Adverse Effects
- Drug Profiles
- Corticosteroids
- ▸ dexamethasone
- Pharmacokinetics
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- flurbiprofen
- Pharmacokinetics
- ketorolac
- Pharmacokinetics
- TOPICAL ANESTHETICS
- Mechanism of Action and Drug Effects
- Indications
- Contraindications
- Adverse Effects
- Interactions
- Drug Profiles
- tetracaine
- Pharmacokinetics
- DIAGNOSTIC DRUGS
- Drug Profiles
- Cycloplegic Mydriatics
- ▸ atropine sulfate
- cyclopentolate
- Mydriatic-Reversal Drug
- dapiprazole
- Ophthalmic Dye
- fluorescein
- ANTIALLERGIC DRUGS
- Antihistamines
- azelastine
- Mast Cell Stabilizers
- cromolyn
- Decongestants
- tetrahydrozoline
- Lubricants and Moisturizers
- ▸ artificial tears
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- DOSAGES
- Ocular Antiallergics
- ♦ NURSING DIAGNOSES
- ♦ PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- Case Study
- Eye Trauma
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- CHAPTER 59 Otic Drugs
- Objectives
- e-Learning Activities
- Companion CD
- evolve Website (http://evolve.elsevier.com/Lilley)
- Drug Profiles
- Glossary
- OVERVIEW OF EAR ANATOMY AND PATHOLOGY
- FIGURE 59-1 Structure of the ear.
- TREATMENT OF EAR DISORDERS
- ANTIBACTERIAL AND ANTIFUNGAL OTIC DRUGS
- Drug Profiles
- Antibacterial Products
- Cortisporin Otic, Ciprodex, Cipro HC Otic, Floxin Otic
- Table 59-1 Common Antibacterial Otic Products
- Table 59-2 Common Antifungal Otic Products
- Antifungal Products
- Cortic, Acetasol HC
- Earwax Emsulfiers
- ▸ carbamide peroxide
- ♦ NURSING PROCESS
- ♦ ASSESSMENT
- ♦ NURSING DIAGNOSES
- PLANNING
- Goals
- Outcome Criteria
- ♦ IMPLEMENTATION
- ♦ EVALUATION
- Patient Teaching Tips
- Points to Remember
- NCLEX Examination Review Questions
- Critical Thinking Activities
- Appendix
- APPENDIX Pharmaceutical Abbreviations
- Bibliography
- General
- Chapter 1
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapter 8
- Chapter 9
- Chapter 10
- Chapter 11
- Chapter 12
- Chapter 13
- Chapter 14
- Chapter 15
- Chapter 16
- Chapter 18
- Chapter 20
- Chapter 21
- Chapter 22
- Chapter 23
- Chapter 24
- Chapter 25
- Chapter 27
- Chapter 28
- Chapter 29
- Chapter 30
- Chapter 31
- Chapter 33
- Chapter 34
- Chapter 35
- Chapter 36
- Chapter 37
- Chapter 38
- Chapter 39
- Chapter 40
- Chapter 41
- Chapter 42
- Chapter 44
- Chapter 46
- Chapters 47 and 48
- Chapter 49
- Chapter 50
- Chapter 51
- Chapter 53
- Chapter 54
- Chapter 57
- Chapter 58
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